...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Virus Research: An International Journal of Molecular and Cellular Virology >Molecular epidemiology of rabies in Colombia 1994-2005 based on partial nucleoprotein gene sequences.
【24h】

Molecular epidemiology of rabies in Colombia 1994-2005 based on partial nucleoprotein gene sequences.

机译：1994-2005年哥伦比亚狂犬病的分子流行病学研究，基于部分核蛋白基因序列。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

One hundred and twenty-four rabies viruses (RABV) were isolated from humans and eight species of mammals in Colombia during 1994-2005. To determine the genetic and reservoir-associated diversity cDNA fragments encoding 88 amino acids at the carboxyl terminus of the nucleoprotein were sequenced and used in phylogenetic analyses. Eight genetic lineages (GL) were characterized. GL1, GL2 and GL3 consisted of dog-associated antigenic variant (AV) 1 RABV, isolated in the centre-east, north and southwest of Colombia, respectively. GL1 is apparently extinct in Colombia. The GL4 were AV3, AV8 and non-determined (ND) AV viruses associated with hematophagous bats. The GL5 and GL6 consisted of AV4 viruses. GL6 isolate was found associated with Tadarida brasiliensis bats. GL5 segregated independently. The GL7 and GL8 segregated independently within clades associated with colonial insectivorous and solitary bats, respectively. Both of these were represented by NDAV viruses. Viruses isolated from humans grouped within GL2, GL3 and GL4, which in turn corresponded to AV1, 3, 8 and ND. Dogs and D. rotundus are the two major rabies reservoirs and vectors in Colombia. Insectivorous bats may also be important rabies reservoirs but spillovers to other species are rare. Our data were consistent with previous studies in which partial Psi, G and L gene sequences were analyzed. Our results confirmed the existence of RABV of unclassified AV in Colombia.
机译：在1994年至2005年期间，从哥伦比亚的人类和8种哺乳动物中分离出了124种狂犬病病毒。为了确定遗传和与储藏有关的多样性，对在核蛋白羧基末端编码88个氨基酸的cDNA片段进行了测序，并用于系统发育分析。表征了八个遗传谱系（GL）。 GL1，GL2和GL3由与狗相关的抗原变体（AV）1 RABV组成，分别在哥伦比亚的中东部，北部和西南部隔离。 GL1在哥伦比亚显然已经灭绝。 GL4是AV3，AV8和与血细胞蝙蝠相关的未确定（ND）AV病毒。 GL5和GL6由AV4病毒组成。发现GL6分离物与巴西Ta（Tadarida brasiliensis）蝙蝠有关。 GL5独立隔离。 GL7和GL8分别独立于与殖民食虫蝙蝠和孤立蝙蝠相关的进化枝中。两者均以NDAV病毒为代表。从人类分离的病毒分为GL2，GL3和GL4，它们分别对应于AV1、3、8和ND。狗和圆形D. rotundus是哥伦比亚的两个主要狂犬病水库和媒介。食虫蝙蝠也可能是重要的狂犬病宿主，但很少有溢出到其他物种的动物。我们的数据与以前的研究一致，在该研究中分析了部分Psi，G和L基因序列。我们的结果证实了哥伦比亚存在未分类AV的RABV。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号