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首页> 外文期刊>Virus Research: An International Journal of Molecular and Cellular Virology >Sequence analysis of the large polymerase (L) protein of the US strain of avian metapneumovirus indicates a close resemblance to that of the human metapneumovirus.
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Sequence analysis of the large polymerase (L) protein of the US strain of avian metapneumovirus indicates a close resemblance to that of the human metapneumovirus.

机译：美国禽肺炎肺炎病毒美国株的大聚合酶（L）蛋白的序列分析表明，它与人偏肺炎病毒非常相似。

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摘要

The complete nucleotide sequence of the large polymerase (L) protein of the avian metapneumovirus subgroup C strain Colorado was determined. The L protein gene of avian pneumovirus Colorado isolate (APV-C) was 6173 nucleotides in length from the gene-start to the gene-end and encoded a polypeptide of 2005 amino acids in length. The length of the L protein of APV-C was exactly the same as that of human metapneumovirus (hMPV) and one amino acid longer than the L protein of APV subgroup A. The L protein of APV-C showed 80% amino acid identity with the L protein of hMPV, but only 64% amino acid identity with the L protein of APV-A. The nucleotide and deduced amino acid sequences were compared with the corresponding sequences of eleven other paramyxoviruses. All six domains characteristic of paramyxovirus L proteins were also observed in the L protein of APV-C. All the polymerase core motifs in domain III were conserved to nearly 100% in the metapneumoviruses. Similarly, the putative ATP-binding motif in domain VI was completely conserved among the metapneumoviruses and differed in length, by one intermediate residue, from other paramyxoviruses. Phylogenetic analysis of the different L proteins also revealed a closer relationship between APV-C and hMPV.
机译：确定了禽偏肺炎病毒亚组C株Colorado的大聚合酶（L）蛋白的完整核苷酸序列。禽肺炎病毒科罗拉多分离株（APV-C）的L蛋白基因从基因开始到基因末端的长度为6173个核苷酸，并编码长度为2005个氨基酸的多肽。 APV-C的L蛋白的长度与人间质肺病毒（hMPV）的长度完全相同，比APV亚组A的L蛋白长一个氨基酸。APV-C的L蛋白显示80％的氨基酸同一性。 hMPV的L蛋白，但与APV-A的L蛋白只有64％的氨基酸同一性。将核苷酸和推导的氨基酸序列与其他十一种副粘病毒的相应序列进行比较。在APV-C的L蛋白中还观察到副粘病毒L蛋白的所有六个结构域特征。域III中的所有聚合酶核心基序在间质肺病毒中均保守至近100％。类似地，结构域VI中的推定ATP结合基序在间质肺病毒中是完全保守的，并且其长度与其他副粘病毒的区别在于一个中间残基。对不同L蛋白的系统进化分析还显示APV-C与hMPV之间存在更紧密的关系。

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