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首页> 外文期刊>Virus Research: An International Journal of Molecular and Cellular Virology >Pathogenicity and genetic characterization of a duck Tembusu virus associated with egg-dropping in Muscovy ducks
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Pathogenicity and genetic characterization of a duck Tembusu virus associated with egg-dropping in Muscovy ducks

机译:与番鸭产蛋相关的鸭Tembusu病毒的致病性和遗传特征

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摘要

Duck Tembusu virus (DTMUV) has spread to the major duck-farming region in China, causing acute egg production drop in Chinese duck population. In this study, we characterized a DTMUV strain (named GD2014) isolated from an egg-production drop duck farm in Guangdong province, South China. The virus was pathogenic to Muscovy duck embryos and caused severe egg production drop for laying Muscovy ducks. The genome sequence of GD2014 shared 97-99% homologies with other waterfowl-origin Tembusu viruses, and shared 89% identities with MM1775 strain isolated from mosquito. Phylogenetic analysis of entire open reading frame (ORF), E gene and NS5 gene indicated that GD2014 belonged to Ntaya group. These results have implications for understanding the orgin, emergence and pathogenicity of DTMUV as well as for the development of vaccines and diagnostics based on epidemiological data. (C) 2016 Elsevier B.V. All rights reserved.
机译:鸭Tembusu病毒(DTMUV)已经传播到中国主要的鸭养殖区,导致中国鸭种群的产蛋量急剧下降。在这项研究中,我们表征了从中国广东省广东省一家产蛋鸭场分离的DTMUV菌株(命名为GD2014)。该病毒对番鸭的胚胎具有致病性,并导致产蛋鸭的产蛋量严重下降。 GD2014的基因组序列与其他源自水禽的Tembusu病毒具有97-99%的同源性,并且与从蚊子中分离出的MM1775菌株具有89%的同一性。对整个开放阅读框(ORF),E基因和NS5基因的系统进化分析表明,GD2014属于Ntaya群。这些结果对于理解DTMUV的起源,出现和致病性以及基于流行病学数据的疫苗和诊断方法的开发都具有意义。 (C)2016 Elsevier B.V.保留所有权利。

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