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首页> 外文期刊>Pesquisa Veterinaria Brasileira >Genetic evaluation of vaccine against bovine brucellosis marketed in Brazil. [Portuguese]Original Title Avaliacao genetica das vacinas contra a brucelose bovina comercializadas no Brasil.
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Genetic evaluation of vaccine against bovine brucellosis marketed in Brazil. [Portuguese]Original Title Avaliacao genetica das vacinas contra a brucelose bovina comercializadas no Brasil.

机译：巴西销售的针对牛布鲁氏菌病的疫苗的遗传评估。 [葡萄牙语]原标题巴西销售的牛布鲁氏菌病疫苗的遗传评估。

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摘要

Vaccine strains B19 and RB51 are administered to cattle for prevention against infection by Brucella abortus. However, there are reports that these vaccines can cause miscarriages. Thus, every miscarriage among vaccinated animals should be thoroughly studied to determine the cause. In Brazil, there are no records on the origin of B19 and RB51 samples used in the preparation of commercial vaccines. Therefore, a study is needed to determine possible mutations in relation to the USDA reference samples of B. abortus due to the fact that vaccine samples could revert to the virulence of the disease. The aim of the present study was to perform a genotype analysis of vaccine strains B19 and RB51 used in Brazil. The methodology was based on the genotyping of marker genes of these vaccine strains by amplification using polymerase chain reaction. The results allowed the identification of the genotype of the B19 and RB51 commercial vaccine available for use on cattle in Brazil. The absence of mutations in the samples tested confirmed the genetic quality of the vaccines and stability of genes analyzed.
机译：向牛施用疫苗株B19和RB51，以防止流产布鲁氏菌感染。但是，有报道说这些疫苗会引起流产。因此，应彻底研究疫苗接种动物中的每次流产，以确定原因。在巴西，没有关于用于制备商业疫苗的B19和RB51样品来源的记录。因此，由于疫苗样品可能恢复为疾病毒力这一事实，需要进行一项研究来确定与流产双歧杆菌USDA参考样品有关的可能突变。本研究的目的是对巴西使用的B19和RB51疫苗株进行基因型分析。该方法基于通过使用聚合酶链反应进行扩增来对这些疫苗株的标记基因进行基因分型。结果可以鉴定出可用于巴西牛的B19和RB51商业疫苗的基因型。测试样品中不存在突变，证实了疫苗的遗传质量和所分析基因的稳定性。

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