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首页> 外文期刊>The International journal of pharmacy practice >Antenatal oral glucose-tolerance test values and pregnancy outcomes
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Antenatal oral glucose-tolerance test values and pregnancy outcomes

机译：产前口服葡萄糖耐量测试值和妊娠结局

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Objective The aim of the present study was to explore the impact of individual blood glucose values (n = 4; i.e. fasting and 1, 2 and 3h following oral glucose administration) obtained during antenatal oral glucose-tolerance testing, together with two different sets of criteria used for diagnosis of gestational diabetes mellitus (GDM) - Carpenter and Coustan Criteria (CCC) and National Diabetes Data Group (NDDG) criteria - in predicting pregnancy outcomes and maternal insulin need. Setting Al Ain Hospital, United Arab Emirates.Method This observational uncontrolled cohort study gained its study subjects from a randomised, controlled, longitudinal, prospective clinical trial performed at Al Ain Hospital, Al Ain, United Arab Emirates. The eligible population was made up of all women (n = 720) who participated in an early screening programme for GDM. Those who had a positive oral glucose-tolerance test (OGTT) based on CCC were included in the study (n = 165). All recruited women with GDM were followed from time of recruitment to 6 months postpartum. The sources of information used were maternal and neonatal medical records and laboratory findings for women both antenatally and postnatally. Results The maternal and neonatal outcomes indicated that the number of abnormally elevated antenatal OGTT values obtained during the diagnosis of GDM was significantly correlated with development of a number of pregnancy complications. Data analysis also indicated that the number of abnormal diagnostic antenatal OGTT values using CCC was significantly correlated with development of postpartum diabetes mellitus (P = 0.044) within 6months of delivery. The number of abnormal OGTT values significantly contributed to insulin need during the index pregnancy (P<0.05). The CCC approach was more sensitive than the NDDG methodology for predicting the onset of GDM and a number of the associated complications.Conclusions The study highlighted the importance of abnormal values for antenatal OGTT in identifying the need for insulin management in women with GDM.
机译：目的本研究的目的是探讨产前口服葡萄糖耐量测试期间获得的单个血糖值（n = 4;即空腹，口服葡萄糖后1、2和3h）的影响，以及两组不同的用于诊断妊娠糖尿病（GDM）的标准-卡彭特和库斯坦标准（CCC）和国家糖尿病数据组（NDDG）的标准-预测妊娠结局和母亲的胰岛素需求。方法这项非观察性队列研究是从在阿拉伯联合酋长国艾因市的艾因医院进行的一项随机，对照，纵向，前瞻性临床试验中获得的研究对象。合格人群由参加GDM早期筛查计划的所有妇女（n = 720）组成。基于CCC的口服葡萄糖耐量试验（OGTT）阳性的患者包括在研究中（n = 165）。从招募到产后6个月，所有接受GDM招募的妇女均得到随访。所使用的信息来源是产前和产后妇女的母体和新生儿病历以及实验室检查结果。结果孕妇和新生儿的结局表明，在诊断GDM期间获得的异常升高的产前OGTT值数量与许多妊娠并发症的发生显着相关。数据分析还表明，在分娩后6个月内，使用CCC进行的异常产前诊断OGTT值的数量与产后糖尿病的发生显着相关（P = 0.044）。 OGTT异常值的数量显着影响了指标妊娠期间的胰岛素需求（P <0.05）。 CCC方法比NDDG方法更灵敏地预测GDM的发作和许多相关并发症。结论该研究强调了产前OGTT异常值在确定GDM妇女胰岛素管理中的重要性。

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