Efficient in vitro expansion of JC virus-specific CD8(+) T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy.

Marzocchetti A; Lima M; Tompkins T; Kavanagh DG; Gandhi RT; ONeill DW; Bhardwaj N; Koralnik IJ

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Efficient in vitro expansion of JC virus-specific CD8(+) T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy.

机译：JCV肽刺激的进展性多灶性白质脑病患者的树突状细胞对JC病毒特异性CD8（+）T细胞应答的有效体外扩增。

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Progressive multifocal leukoencephalopathy (PML) is a demyelinating disease of the brain caused by JC virus (JCV) for which there is no cure. PML patients who have JCV-specific CD8(+) cytotoxic T lymphocytes (CTL) in their blood have a better clinical outcome. We compared JCV-specific CTL responses in vitro elicited either by JCV peptide-loaded dendritic cells (DC) or by direct peptide stimulation of lymphocytes from 20 HLA-A0201(+) healthy controls, HIV(+) and PML patients. JCV peptide-loaded DC elicited a stronger CTL expansion in 13/15 responders. DC can induce a potent JCV-specific CTL response in vitro, and may constitute a promising approach for PML immunotherapy.

机译：进行性多灶性白质脑病（PML）是由无法治愈的JC病毒（JCV）引起的大脑脱髓鞘疾病。 PML患者的血液中具有JCV特异性CD8（+）细胞毒性T淋巴细胞（CTL），其临床结局更好。我们比较了体外JCV特异性CTL反应，该反应是由JCV肽加载的树突状细胞（DC）或直接肽刺激20名HLA-A0201（+）健康对照，HIV（+）和PML患者的淋巴细胞引起的。载有JCV肽的DC在13/15应答者中引起更强的CTL扩展。 DC可以在体外诱导强效的JCV特异性CTL反应，并且可能构成PML免疫疗法的有前途的方法。

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《Virology》 |2009年第2期|共5页
作者
Marzocchetti A; Lima M; Tompkins T; Kavanagh DG; Gandhi RT; ONeill DW; Bhardwaj N; Koralnik IJ;
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正文语种 eng
中图分类人体病毒学（致病病毒）;医学微生物学（病原细菌学、病原微生物学）;人体病毒学（致病病毒）;
关键词
Adult; Aged; CD8-Positive T-Lymphocytes; Cell Proliferation; Dendritic Cells; 成年人; 老年人; CD8阳性T淋巴细胞; 树突细胞; HIV感染; 脑白质病; 进行性多病灶;

机译：Adult;Aged;CD8-Positive T-Lymphocytes;Cell Proliferation;Dendritic Cells;成年人;老年人;CD8阳性T淋巴细胞;树突细胞;HIV感染;脑白质病;进行性多病灶;

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专利

1. Efficient in vitro expansion of JC virus-specific CD8(+) T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy. [J] . Marzocchetti A, Lima M, Tompkins T, Virology . 2009,第2期

机译：JCV肽刺激的进展性多灶性白质脑病患者的树突状细胞对JC病毒特异性CD8（+）T细胞应答的有效体外扩增。
2. A prospective study demonstrates an association between JC virus-specific cytotoxic T lymphocytes and the early control of progressive multifocal leukoencephalopathy. [J] . Du-Pasquier RA, Kuroda MJ, Zheng Y, Brain: A journal of neurology . 2004,第Pta9期

机译：一项前瞻性研究表明，JC病毒特异性细胞毒性T淋巴细胞与进行性多灶性白质脑病的早期控制之间存在关联。
3. JCV-specific cellular immune response correlates with a favorable clinical outcome in HIV-infected individuals with progressive multifocal leukoencephalopathy. [J] . Du-Pasquier RA, Clark KW, Smith PS, Journal of neurovirology . 2001,第4期

机译：在进行性多灶性白质脑病的HIV感染者中，JCV特异性细胞免疫反应与良好的临床结果相关。
4. CD8 T-Cell - Dendritic Cell Cross-Talk [C] . K.L. Wong, D.M. Kemeny Collegium Internationale Allergologicum . 2007

机译：CD8 T细胞 - 树突细胞串扰
5. Plasmacytoid and respiratory dendritic cells control the magnitude of the virus-specific CD8 T cell response to lethal dose influenza virus infections. [D] . Langlois, Ryan Andrew. 2010

机译：浆细胞样细胞和呼吸道树突状细胞控制着对致命剂量流感病毒感染的病毒特异性CD8 T细胞反应的强度。
6. Efficient in vitro Expansion of JC virus-Specific CD8+ T-Cell Responses by JCV peptide-stimulated Dendritic Cells from patients with Progressive Multifocal Leukoencephalopathy [O] . Angela Marzocchetti, Marco Lima, Troy Tompkins, -1

机译：进行性多灶性白质脑病患者的JCV肽刺激的树突状细胞有效扩展JC病毒特异性CD8 + T细胞反应
7. Corrigendum to “Efficient in vitro expansion of JC virus-specific CD8+ T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy” Virology 383 (2009) 173–177 [O] . Marzocchetti Angela, Lima Marco, Tompkins Troy, 2010

机译：有关“进行性多灶性白质脑病患者的JCV肽刺激的树突状细胞对JC病毒特异性CD8 + T细胞应答的有效体外扩增”的勘误Virology 383（2009）173-177

Efficient in vitro expansion of JC virus-specific CD8(+) T-cell responses by JCV peptide-stimulated dendritic cells from patients with progressive multifocal leukoencephalopathy.

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