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首页> 外文期刊>Virology >Duck hepatitis B virus covalently closed circular DNA appears to survive hepatocyte mitosis in the growing liver
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Duck hepatitis B virus covalently closed circular DNA appears to survive hepatocyte mitosis in the growing liver

机译：鸭乙型肝炎病毒共价封闭的环状DNA在存活的肝细胞中似乎能存活肝细胞有丝分裂

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摘要

Nucleos(t)ide analogues that inhibit hepatitis B virus (HBV) DNA replication are typically used as monotherapy for chronically infected patients. Treatment with a nucleos(t)ide analogue eliminates most HBV DNA replication intermediates and produces a gradual decline in levels of covalently closed circular DNA (cccDNA), the template for viral RNA synthesis. It remains uncertain if levels of cccDNA decline primarily through hepatocyte death, or if loss also occurs during hepatocyte mitosis. To determine if cccDNA survives mitosis, growing ducklings infected with duck hepatitis B virus (DHBV) were treated with the nucleoside analogue, Entecavir. Viremia was suppressed at least 105-fold, during a period when average liver mass increased 23-fold. Analysis of the data suggested that if cccDNA synthesis was completely inhibited, at least 49% of cccDNA survived hepatocyte mitosis. However, there was a large duck-to-duck variation in cccDNA levels, suggesting that low level cccDNA synthesis may contribute to this apparent survival through mitosis.
机译：抑制乙型肝炎病毒（HBV）DNA复制的核苷类似物通常用作慢性感染患者的单一疗法。用核苷酸类似物处理可消除大多数HBV DNA复制中间体，并逐渐降低共价闭合环状DNA（cccDNA）（病毒RNA合成模板）的水平。 cccDNA的水平是否主要通过肝细胞死亡而下降，或者在肝细胞有丝分裂期间是否也发生丢失，尚不确定。为了确定cccDNA是否能在有丝分裂中幸存，用核苷类似物Entecavir处理感染了鸭乙型肝炎病毒（DHBV）的生长中的小鸭。在平均肝脏质量增加23倍的时期内，病毒血症被抑制了至少105倍。数据分析表明，如果完全抑制cccDNA的合成，则至少49％的cccDNA可以存活肝细胞有丝分裂。但是，cccDNA水平之间存在较大的鸭对鸭差异，这表明低水平的cccDNA合成可能通过有丝分裂促进了这种明显的存活。

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