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A mathematical model for absorption of intestinal villus

机译：肠道绒毛吸收的数学模型

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Physiologists have done many researches on the mechanism of the intestinal villus absorption. Since the 1970s, Haljamae and Jodal presented serial experimental reports. They believed that there is a counter current mechanism in the intestinal villus,so the osmolality in the tip is 2--3 times greater than that in the base. In a conclusive article, Jodal believed that, in accordance with the anatomic considerations, the blood flows from the base to the tip of the intestinal villus in the central arterial vessel, and then descends from the tip to the base in the peripheral capillaries and veins, so that there are opposite blood flowing directions in the intestinal villus which makes the countercurrent mechanism possible. Second, the active pumping ofNaCl and passive absorption of water into the intestinal villus increase the plasma osmolality in the peripheral capillaries and veins, and the small change in plasma osmolality is multiplied along the length of the villus, with the result that the tip osmolality is considerably higher than in the base, which is helpful in passive water absorption. He also believed that the importance of this mechanism is to prevent absorbing harmful substances into the intestinal villus.
机译：生理学家对肠绒毛吸收的机制进行了许多研究。自1970年代以来，Haljamae和Jodal提出了系列实验报告。他们认为小肠绒毛中存在逆流机制，因此尖端的重量克分子渗透压浓度是基部的重量克分子渗透浓度的2--3倍。乔达尔在结论性文章中认为，根据解剖学考虑，血液从中央动脉血管的小肠绒毛的底部流到尖端，然后在周围毛细血管和静脉中从尖端流到底部，因此肠绒毛中血液的流动方向相反，这使得逆流机制成为可能。其次，主动将NaCl泵入和被动吸收水分到肠绒毛中会增加外周毛细血管和静脉中的血浆渗透压，并且血浆渗透压的微小变化会沿着绒毛的长度成倍增加，结果是尖端渗透压是大大高于基础，这有助于被动吸水。他还认为，这种机制的重要性在于防止有害物质吸收到肠绒毛中。

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