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首页> 外文期刊>Virology >Caprine arthritis-encephalitis virus-infected goats can generate human immunodeficiency virus-gp120 cross-reactive antibodies
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Caprine arthritis-encephalitis virus-infected goats can generate human immunodeficiency virus-gp120 cross-reactive antibodies

机译：感染山羊关节炎-脑炎病毒的山羊可产生人类免疫缺陷病毒-gp120交叉反应抗体

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摘要

Lentiviruses display surprisingly disparate clinical manifestations in their specific hosts, share complex genetic structures, and exhibit extensive diversity, particularly in their envelope genes. The envelope protein, gp135, of caprine arthritis-encephalitis virus (CAEV) has minimal primary sequence homology to gp120, the envelope protein of human immunodeficiency virus (HIV). Nevertheless, they bear certain similarities in that they both possess five variable regions, both are heavily glycosylated, and both share short sequence motifs. We establish a further relationship and demonstrate that some goats, infected with CAEV, possess gp135-specific antibodies which cross-react with gp120 from several HIV strains provided the protein is expressed in insect cells. We show that, although the cross-reactivity of these immunoglobulins depends on the level of glycosylation, nevertheless, some antibodies recognize the protein epitopes on gp120, at least some of which are linear in character. Further characterization of this unexpected cross-reaction will define its potential therapeutic utility.
机译：慢病毒在其特定宿主中显示出令人惊讶的完全不同的临床表现，共享复杂的遗传结构，并且表现出广泛的多样性，尤其是在其包膜基因中。山羊关节炎-脑炎病毒（CAEV）的包膜蛋白gp135与人免疫缺陷病毒（HIV）的包膜蛋白gp120具有极小的一级序列同源性。然而，它们具有某些相似性，因为它们都具有五个可变区，都被高度糖基化，并且都具有短序列基序。我们建立了进一步的关系，并证明了一些感染了CAEV的山羊具有gp135特异性抗体，只要该蛋白在昆虫细胞中表达，它们就可以与来自多个HIV株的gp120交叉反应。我们显示，尽管这些免疫球蛋白的交叉反应性取决于糖基化的水平，但是，有些抗体识别gp120上的蛋白质表位，至少其中一些具有线性特征。这种意外的交叉反应的进一步表征将定义其潜在的治疗用途。

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