Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells.

Shinya E; Owaki A; Shimizu M; Takeuchi J; Kawashima T; Hidaka C; Satomi M; Watari E; Sugita M; Takahashi H

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Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells.

机译：内源性表达的HIV-1 nef下调了未成熟树突状细胞中的抗原呈递分子，不仅是I类MHC，而且还下调了CD1a。

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The effects of Nef molecules on immature dendritic cells (iDCs) were analyzed using recombinant human immunodeficiency virus type 1 (HIV-1) with intact nef gene, pseudotyped with vesicular stomatitis virus glycoprotein, HIV/VSV-G/+Nef. When iDCs were infected with HIV/VSV-G/+Nef, the surface expression of CD1a, a molecule for presenting glycolipid/lipid antigens, was selectively down-regulated among CD1 molecules (CD1a, -b, -c, and -d) as well as class I MHC. Moreover, the CD1a molecules were also down-modulated and co-localized with DsRed2-tagged-Nef in CD1a-transfected cells. Their co-localization was dependent upon CD1a cytoplasmic tail and the CD1a was redistributed from cell surface to LAMP-1+ late endosomal/lysosomal compartment. These findings reveal that the HIV-1-Nef interferes with the intracellular trafficking of CD1a, and suggest the involvement of CD1a-restricted immune effectors in the protective immunity against HIV-1 infection, which implicates the feasibility of virus-derived glycolipid/lipid antigens together with epitope peptides for the vaccine development.

机译：使用具有完整nef基因的重组人免疫缺陷病毒1型（HIV-1）（用水泡性口炎病毒糖蛋白HIV / VSV-G / + Nef假型）重组Nef分子对未成熟树突状细胞（iDC）的作用进行了分析。当iDC感染HIV / VSV-G / + Nef时，在CD1分子（CD1a，-b，-c和-d）中选择性下调了呈递糖脂/脂抗原的分子CD1a的表面表达。以及I类MHC。此外，在CD1a转染的细胞中，CD1a分子也被下调并与DsRed2-tagged-Nef共定位。它们的共定位取决于CD1a胞质尾巴，并且CD1a从细胞表面重新分布到LAMP-1 +内体/溶酶体晚期区室。这些发现表明，HIV-1-Nef干扰了CD1a的细胞内运输，并暗示了受CD1a限制的免疫效应子参与了针对HIV-1感染的保护性免疫，这暗示了病毒衍生的糖脂/脂质抗原的可行性与表位肽一起用于疫苗开发。

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《Virology》 |2004年第1期|共11页
作者
Shinya E; Owaki A; Shimizu M; Takeuchi J; Kawashima T; Hidaka C; Satomi M; Watari E; Sugita M; Takahashi H;
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正文语种 eng
中图分类基础医学;
关键词
HIV-1; Antigens; Myosin Heavy Chains; 抗原; 肌球蛋白重链;

机译：HIV-1;Antigens;Myosin Heavy Chains;抗原;肌球蛋白重链;

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专利

1. Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells. [J] . Shinya E, Owaki A, Shimizu M, Virology . 2004,第1期

机译：内源性表达的HIV-1 nef下调了未成熟树突状细胞中的抗原呈递分子，不仅是I类MHC，而且还下调了CD1a。
2. Association of distinct tetraspanins with MHC class II molecules at different subcellular locations in human immature dendritic cells. [J] . Engering A, Pieters J International immunology. . 2001,第2期

机译：不同的四跨膜蛋白与人类未成熟树突状细胞不同亚细胞位置的II类MHC分子缔合。
3. Fibronectin-binding protein I of Streptococcus pyogenes promotes T cell-independent proliferation of murine B lymphocytes and enhances the expression of MHC class II molecules on antigen-presenting cells. [J] . Medina E, Talay SR, Chhatwal GS, International immunology. . 1998,第11期

机译：化脓性链球菌的纤连蛋白结合蛋白I促进了鼠B淋巴细胞的T细胞非依赖性增殖，并增强了MHC II类分子在抗原呈递细胞上的表达。
4. MONOCYTES SUPPRESS IMMUNE RESPONSES OF PERIPHERAL BLOOD LYMPHOCYTES: POSSIBLE IMPLICATION OF IMMATURE DENDRITIC CELLS. [C] . M. YAMASHITA, Y. KATAKURA, S. MATSUMOTO, Annual Meeting of the Japanese Association for Animal Cell Technology . 2003

机译：单核细胞抑制外周血淋巴细胞的免疫应答：未成熟树突细胞的可能含义。
5. Intracellular trafficking of MHC-I in normal and HIV-1 Nef expressing cells [D] . Schaefer, Malinda R. 2008

机译：正常和HIV-1 Nef表达细胞中MHC-1的细胞内运输
6. HIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking. [O] . Ling Yi, Tilman Rosales, Jeremy J. Rose, 2010

机译：HIV-1 Nef在其整个贩运路线中都与MHC-1的一个亚群结合并通过扰乱顺行和逆行贩运来下调MHC-1。
7. Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells [O] . Shinya Eiji, Owaki Atsuko, Shimizu Masumi, 2004

机译：内源性表达的HIV-1 nef下调未成熟树突状细胞中的抗原呈递分子，不仅是I类MHC，而且还下调CD1a

Endogenously expressed HIV-1 nef down-regulates antigen-presenting molecules, not only class I MHC but also CD1a, in immature dendritic cells.

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