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首页> 外文期刊>Western journal of nursing research >Achieving Tenure: Planning for a Marathon, Not a Sprint
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Achieving Tenure: Planning for a Marathon, Not a Sprint

机译：实现终身制：计划马拉松，而不是短跑

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In the pediatric population, especially in early infancy, the activity of brown adipose tissue (BAT) is the highest. Further in life BAT is more active in individuals with a lower body mass index and one can expect that BAT is protective against childhood obesity. The development of BAT throughout the whole life can be regulated by genetic, endocrine, and environmental factors. Three distinct adipose depots have been identified: white, brown, and beige adipocytes. The process by which BAT can become beige is still unclear and is an area of intensive research. The “browning agents” increase energy expenditure through the production of heat. Numerous factors known as “browning agents” have currently been described. In humans, recent studies justify a notion of a role of novel myokines: irisin and fibroblast growth factor 21 (FGF21) in the metabolism and development of obesity. This review describes a possible role of irisin and FGF21 in the pathogenesis of obesity in children.
机译：在儿科人群中，尤其是在婴儿早期，棕色脂肪组织（BAT）的活性最高。在生活中，BAT在较低的体重指数人群中更活跃，人们可以期望BAT可以预防儿童肥胖。 BAT在一生中的发展都可以通过遗传，内分泌和环境因素来调节。已经确定了三个不同的脂肪库：白色，棕色和米色的脂肪细胞。 BAT变成米色的过程仍不清楚，并且是深入研究的领域。 “褐变剂”通过产生热量增加了能量消耗。当前已经描述了许多被称为“褐变剂”的因素。在人类中，最近的研究证明了一种新颖的肌肉因子的作用：虹膜素和成纤维细胞生长因子21（FGF21）在肥胖症的代谢和发育中的作用。这篇综述描述了虹膜素和FGF21在儿童肥胖的发病机理中的可能作用。

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