1,2,3,6-tetra-O-galloyl-β-D-allopyranose gallotannin isolated, from Euphorbia jolkini, attenuates LPS-induced nitric oxide production in macrophages

Park S.-B.; Kim M.-S.; Lee H.S.; Lee S.H.; Kim S.-H.

首页> 外文期刊>Phytotherapy research: PTR >1,2,3,6-tetra-O-galloyl-β-D-allopyranose gallotannin isolated, from Euphorbia jolkini, attenuates LPS-induced nitric oxide production in macrophages

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1,2,3,6-tetra-O-galloyl-β-D-allopyranose gallotannin isolated, from Euphorbia jolkini, attenuates LPS-induced nitric oxide production in macrophages

机译：分离自大戟属的1,2,3,6-四-O-galloyl-β-D-allopyranose没食子醛没食子碱可减弱LPS诱导巨噬细胞中一氧化氮的产生。

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Nitric oxide (NO) is a pleiotropic regulator, critical to numerous biological processes, including vasodilatation and macrophage-mediated immunity. Macrophages express inducible NO synthase (iNOS) and produce NO after lipopolysaccharide (LPS) stimulation. Gallotannins are water-soluble polyphenols with wide-ranging biological activities. Various chemical structures of gallotannins occurring in medicinal and food plants that are used worldwide showed several remarkable biological and pharmacological activities. In the present study, we examined the inhibitory effects of gallotannin 1,2,3,6-tetra-O-galloyl-β-D-allopyranose (GT24) isolated from Euphorbia jolkini on the LPS-induced NO production and underlying mechanisms of action. GT24 dose-dependently decreased LPS-induced NO production and iNOS expression in J774A.1 macrophages. In addition, GT24 inhibited LPS-induced activation of nuclear factor (NF)-κB as indicated by inhibition of degradation of I-κBα, nuclear translocation of NF-κB, and NF-κB dependent gene reporter assay. Our results suggest that GT24 possesses an inhibitory effect on the LPS-induced inflammatory reaction.

机译：一氧化氮（NO）是一种多效调节剂，对许多生物过程（包括血管舒张和巨噬细胞介导的免疫）至关重要。巨噬细胞表达诱导型NO合酶（iNOS），并在脂多糖（LPS）刺激后产生NO。 Gallotannins是具有广泛生物活性的水溶性多酚。在全世界范围内使用的药用和食用植物中，没食子鞣质的各种化学结构显示出几种显着的生物学和药理活性。在本研究中，我们研究了从大戟大戟中分离得到的没食子鞣质1,2,3,6-四-O-没食子酰基-β-D-铝吡喃糖（GT24）对LPS诱导的NO产生及其潜在作用机制的抑制作用。 GT24剂量依赖性降低J774A.1巨噬细胞中LPS诱导的NO产生和iNOS表达。此外，GT24抑制LPS诱导的核因子（NF）-κB活化，这可通过抑制I-κBα的降解，NF-κB的核易位和NF-κB依赖性基因报告基因检测来表明。我们的结果表明，GT24对LPS诱导的炎症反应具有抑制作用。

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《Phytotherapy research: PTR》 |2010年第9期|共5页
作者
Park S.-B.; Kim M.-S.; Lee H.S.; Lee S.H.; Kim S.-H.;
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正文语种 eng
中图分类中草药治疗学（八法论治）;
关键词
1; 2; 3; 6-tetra-O-galloyl-β-D-allopyranose; Gallotannin; Inflammation; Nitric oxide; Nuclear factor-κB;

机译：1;2;3;6-四-O-galloyl-β-D-allopyranose;加洛宁;炎症;一氧化氮;核因子-κB;

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1. 1,2,3,6-tetra-O-galloyl-β-D-allopyranose gallotannin isolated, from Euphorbia jolkini, attenuates LPS-induced nitric oxide production in macrophages [J] . Park S.-B., Kim M.-S., Lee H.S., Phytotherapy research: PTR . 2010,第9期

机译：分离自大戟属的1,2,3,6-四-O-galloyl-β-D-allopyranose没食子醛没食子碱可减弱LPS诱导巨噬细胞中一氧化氮的产生。
2. Chemical constituents isolated from the Mongolian medicinal plant Sophora alopecuroides L. and their inhibitory effects on LPS-induced nitric oxide production in RAW 264.7 macrophages [J] . Kwon Jaeyoung, Basnet Sunita, Lee Jin Woo, Bioorganic and Medicinal Chemistry Letters . 2015,第16期

机译：蒙古药用植物槐（Sophora alopecuroides L.）的化学成分及其对脂多糖诱导的RAW 264.7巨噬细胞一氧化氮生成的抑制作用
3. 6,6′-Bieckol, isolated from marine alga Ecklonia cava, suppressed LPS-induced nitric oxide and PGE 2 production and inflammatory cytokine expression in macrophages: The inhibition of NFκB [J] . YangY.-I., ShinH.-C., KimS.H., International immunopharmacology . 2012,第3期

机译：从海藻Ecklonia cava分离得到的6,6'-Bieckol可抑制LPS诱导的一氧化氮和PGE 2的产生以及巨噬细胞中炎性细胞因子的表达：NFκB的抑制
4. Production of nitric oxide, tumor necrosis factor-a and interleukin-6 by RAW264.7 macrophage cells treated with lactic acid bacteria isolated from kimchi [C] . Haeng Jeon Hur, Ki Won Lee, Hyong Joo Lee International Conference on Food Factors . 2004

机译：用乳酸菌分离的乳酸菌治疗的Raw264.7巨噬细胞生产一氧化氮，肿瘤坏死因子-A和白细胞介素-6
5. Regulation of the LPS-induced cytotoxic response in murine macrophages: Roles of nitric oxide and autocrine IFN-beta;. [D] . Jacobs, Aaron Thomas. 2003

机译：LPS诱导的小鼠巨噬细胞毒性反应的调节：一氧化氮和自分泌IFN-β的作用。
6. Achillea millefolium L. Essential Oil Inhibits LPS-Induced Oxidative Stress and Nitric Oxide Production in RAW 264.7 Macrophages [O] . Su-Tze Chou, Hsin-Yi Peng, Jaw-Cherng Hsu, 2013

机译：Achillea millefolium L.精油抑制RAW 264.7巨噬细胞中LPS诱导的氧化应激和一氧化氮的产生
7. Gallotannin Isolated from Euphorbia Species, 1,2,6-Tri-O-galloyl-.BETA.-D-allose, Decreases Nitric Oxide Production through Inhibition of Nuclear Factor-.KAPPA.>B and Downstream Inducible Nitric Oxide Synthase Expression in Macrophages [O] . Mi-Sun Kim, Seung-Bin Park, Kyoungho Suk, 2009

机译：从大戟属物种中分离的Gallotannin，1,2,6-三-Calloyl-.beta.-D- allose，通过抑制核因子-κA来降低一氧化氮产生。> B和下游诱导型巨噬细胞中的巨噬细胞

1,2,3,6-tetra-O-galloyl-β-D-allopyranose gallotannin isolated, from Euphorbia jolkini, attenuates LPS-induced nitric oxide production in macrophages

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