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首页> 外文期刊>Carbon: An International Journal Sponsored by the American Carbon Society >Covalent functionalization enables good dispersion and anisotropic orientation of multi-walled carbon nanotubes in a poly(L-lactic acid) electrospun nanofibrous matrix boosting neuronal differentiation
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Covalent functionalization enables good dispersion and anisotropic orientation of multi-walled carbon nanotubes in a poly(L-lactic acid) electrospun nanofibrous matrix boosting neuronal differentiation

机译：共价官能化使多壁碳纳米管在聚（L-乳酸）电纺纳米纤维基质中具有良好的分散性和各向异性取向，从而促进神经元分化

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A biocompatible porous scaffold obtained via electrospinning a nanocomposite solution of poly(L-lactic acid) and 4-methoxyphenyl functionalized multi-walled carbon nanotubes is presented here for the first time for the enhancement of neurite outgrowth. Optimization of blend preparation and deposition parameters paves the way to the obtainment of defect-free random networks of nanofibers with homogeneous diameters in the hundreds of nanometers length scale. The tailored covalent functionalization of nanotube surfaces allows a homogeneous dispersion of the nanofillers within the polymer matrix, diminishing their natural tendency to aggregate and form bundles. This results in a remarkable effect on the crystallization temperature, as evidenced through differential scanning calorimetry. Furthermore, transmission electron microscopy shows carbon nanotubes anisotropically aligned along the fiber axes, a feature believed to enhance neurite adhesion and growth. Indeed, microscopy images show neurites extension along the direction of nanofibers, highlighting the extreme relevance of scaffold morphology in engineering complex tissue environments. Furthermore, a remarkable effect on increasing the neurite outgrowth results when using the fibrous scaffold containing dispersed carbon nanotubes in comparison with an analogous one made of only polymer, providing further evidence of the key role played by carbon nanostructures in inducing neuronal differentiation. (C) 2015 Elsevier Ltd. All rights reserved.
机译：本文首次提出了通过静电纺丝聚（L-乳酸）和4-甲氧基苯基官能化的多壁碳纳米管的纳米复合溶液获得的生物相容性多孔支架，以增强神经突的生长。共混物制备和沉积参数的优化为获得具有数百纳米长径均一直径的无缺陷纳米纤维随机网络铺平了道路。纳米管表面的定制共价官能化功能可将纳米填料均匀分散在聚合物基质中，从而减少了其自然聚集和形成束的趋势。如差示扫描量热法所证明的，这对结晶温度产生显着影响。此外，透射电子显微镜显示碳纳米管沿纤维轴各向异性排列，该特征被认为可增强神经突的粘附和生长。确实，显微镜图像显示神经突沿纳米纤维的方向延伸，突显了在工程复杂组织环境中支架形态的极端相关性。此外，与仅由聚合物制成的类似物相比，当使用含有分散的碳纳米管的纤维状支架时，对增加神经突生长有显着效果，进一步证明了碳纳米结构在诱导神经元分化中所起的关键作用。 （C）2015 Elsevier Ltd.保留所有权利。

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