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首页> 外文期刊>Chinese science bulletin >SUN Dayong, ZHU Yanshi, LIU Ziyang, LIU Guizhen, zz:GUO Xinghua; ZHAN Ruiyun; LlU Shuying
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SUN Dayong, ZHU Yanshi, LIU Ziyang, LIU Guizhen, zz:GUO Xinghua; ZHAN Ruiyun; LlU Shuying

机译：sun DA用, zh u Y案是, l IU Z i样, l IU GUI真, 这种:G UO xing化; zh ANR UI韵; l lush u影

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摘要

THE bioactivity study of C_(60) and its relative derivatives is of considerable importance. Because C_(60) itself is a non-polar molecule and very difficult to dissolve in common polar solvents, its application in biochemistry field is greatly impeded. Successful preparation of some water-soluble C_(60) derivatives will be helpful. Friedman found that a water-soluble C_(60) derivative, [HOCO-(CH_2)_2CONH(CH_2)_2-C_6H_4]_2C_(61), has a bioactivity of inhibition of the HIVP in 1993. Huang reported thatwater-soluble C_(60) lipoplast has sharp cancerocidal activity to human uteri' s cancer cells. Recently, Chiang studied the scavenging ability of water-soluble multi-hy-droxyl C_(60) derivative-fullerenols to superoxygen anion radical by chemical luminescent determination. The results indicated an excellent efficiency of fullerenols in eliminating super-oxygen anion radical produced by xanthine/xanthine oxidase. So far, the study on the scavenging of fullerenols to hydroxyl-radical has not been reported.
机译：C_（60）及其相对衍生物的生物活性研究具有重要意义。由于C_（60）本身是非极性分子，很难溶于普通极性溶剂中，因此极大地限制了其在生物化学领域的应用。成功制备某些水溶性C_（60）衍生物将有所帮助。 Friedman发现1993年水溶性C_（60）衍生物[HOCO-（CH_2）_2CONH（CH_2）_2-C_6H_4] _2C_（61）具有抑制HIVP的生物活性。 60）脂质体对人子宫癌细胞具有强烈的杀癌活性。最近，Chiang通过化学发光法研究了水溶性多羟基C_（60）衍生物-富勒烯醇对超氧阴离子自由基的清除能力。结果表明富勒烯醇在消除由黄嘌呤/黄嘌呤氧化酶产生的超氧阴离子自由基方面具有优异的效率。迄今为止，还没有关于富勒烯醇清除为羟基自由基的研究。

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