8-chIoroadenosine induces apoptosis in human MOLT-4 cell line

WANG Xiantao; ZHENG Dexian; LIU Rui; LIU Yanxin; XIAO Sheng; MIN Jimei; ZHENG Ping; ZHANG Line; LIU Shi Man

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8-chIoroadenosine induces apoptosis in human MOLT-4 cell line

机译：8-chroroadenosine诱导人MOLT-4细胞凋亡

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THE 8-chloroadenosine (8CA) is a novel analog of adenosine synthesized in the National Research Laboratories of Natural and Biomimetic Drugs. Fang et al. reported that 8CA is capable of inhibiting the cell growth in vitro of mouse liver cancer cells and human HL-60 and K562 of human leukemic cell lines. In the present study, we showed that 8CA could induce human leukemia MOLT-4 T lymphocytes to die by apoptosis and that the apoptosis could be inhibited by bcl-2 overexpression. 8CA-induced-cell deathprovided a new experimental model for studying the mechanism of apoptosis and screening anti-tumor drugs for clinical trials.

机译：8-氯腺苷（8CA）是在国家自然和仿生药物研究实验室合成的新型腺苷类似物。方等。报道8CA能够在体外抑制小鼠肝癌细胞和人白血病细胞系HL-60和K562的细胞生长。在本研究中，我们表明8CA可以诱导人白血病MOLT-4 T淋巴细胞通过凋亡而死亡，而凋亡可能被bcl-2过表达抑制。 8CA诱导的细胞死亡提供了一个新的实验模型，用于研究细胞凋亡的机制并筛选抗肿瘤药物进行临床试验。

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来源
《Chinese science bulletin》 |1997年第7期|共6页
作者
WANG Xiantao; ZHENG Dexian; LIU Rui; LIU Yanxin; XIAO Sheng; MIN Jimei; ZHENG Ping; ZHANG Line; LIU Shi Man;
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正文语种 eng
中图分类自然科学现状及发展;
关键词
8-chloroadenosine; apoptosis; MOLT-4 cells;

机译：8-氯腺苷;凋亡;MOLT-4细胞;

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专利

1. 8-chIoroadenosine induces apoptosis in human MOLT-4 cell line [J] . WANG Xiantao, ZHENG Dexian, LIU Rui, Chinese science bulletin . 1997,第7期

机译：8-chroroadenosine诱导人MOLT-4细胞凋亡
2. Wortmannin-enhanced X-ray-induced apoptosis of human T-cell leukemia MOLT-4 cells possibly through the JNK/SAPK pathway [J] . Tomita M., Suzuki N., Matsumoto Y., Radiation Research: Official Organ of the Radiation Research Society . 2003,第4期

机译：渥曼青霉素增强的X射线可能通过JNK / SAPK途径诱导人T细胞白血病MOLT-4细胞凋亡
3. D-Pinitol treatment induced the apoptosis in human leukemia MOLT-4 cells by improved apoptotic signaling pathway [J] . Xiangmei Yao, Keqian Shi, Yanmei Yang, Saudi Journal of Biological Sciences . 2020,第8期

机译：通过改善的凋亡信号通路诱导人白血病Molt-4细胞的凋亡诱导凋亡
4. Ugonin K induces Cell Cycle Arrest and Apoptosis through Reactive oxygen species/Apoptosis Signal Pathway in Human Skin Cancer Cells [C] . Leong-Perng Chan, Tzung-Han Chou, Guey-Horng Wang, International Conference on Manufacturing Science and Engineering . 2013

机译：Ugonin K通过在人体皮肤癌细胞中的活性氧物质/凋亡信号途径诱导细胞周期停滞和细胞凋亡
5. Human Cytomegalovirus Infection Induces Apoptosis within Human Neural Precursor Cells under Low Oxygen Conditions. [D] . Hildreth, Richard L., III. 2012

机译：在低氧条件下，人巨细胞病毒感染会诱导人神经前体细胞内的凋亡。
6. D-Pinitol treatment induced the apoptosis in human leukemia MOLT-4 cells by improved apoptotic signaling pathway [O] . Xiangmei Yao, Keqian Shi, Yanmei Yang, 2020

机译：D-山梨醇治疗通过改善细胞凋亡信号通路诱导人白血病MOLT-4细胞凋亡
7. Telomere attrition, and chromosome instability via downregulation of TRF2 contributes to arsenic trioxide-induced apoptosis of human T-cell leukemia cell line molt-4 cells [O] . Yangwen Jiao, Weifang Zhang, Junqing Liu, 2007

机译：通过TRF2的下调的端粒磨损和染色体不稳定性有助于砷的三氧化砷诱导人T细胞白血病细胞系Molt-4细胞的凋亡

8-chIoroadenosine induces apoptosis in human MOLT-4 cell line

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