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Real-time measurements and modelling on dynamic behaviour of SonoVue bubbles based on light scattering technology

机译:基于光散射技术的SonoVue气泡动态行为的实时测量和建模

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摘要

The dynamic behaviour of SonoVue microbubbles, a new generation ultrasound contrast agent, is investigated in real time with light scattering method. Highly diluted SonoVue microbubbles are injected into a diluted gel made of xanthan gum and water. The responses of individual SonoVue bubbles to driven ultrasound pulses are measured. Both linear and nonlinear bubble oscillations are observed and the results suggest that SonoVue microbubbles can generate strong nonlinear responses. By fitting the experimental data of individual bubble responses with Sarkar's model, the shell coating parameter of the bubbles and dilatational viscosity is estimated to be 7.0 nm.s.Pa.
机译:采用光散射法实时研究了新一代超声造影剂SonoVue微泡的动态行为。将高度稀释的SonoVue微泡注入由黄原胶和水制成的稀释凝胶中。测量各个SonoVue气泡对驱动的超声脉冲的响应。观察到线性和非线性气泡振荡,结果表明SonoVue微气泡可以产生强烈的非线性响应。通过用Sarkar模型拟合单个气泡响应的实验数据,气泡的外壳涂层参数和膨胀粘度估计为7.0nm.s.Pa。

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