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Comparative genome analysis of deleted genes in Shigella flexneri 2a strain 301

机译：弗氏志贺氏菌2a菌株301中缺失基因的比较基因组分析

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摘要

Comparative genome analysis is performed between Shigella flexneri 2a strain 301 and its close relatives, the non-pathogenic E. coli K-12 strain MG1655. Result shows that there are 136 DNA segments whose size is larger than 1000 bp absent from Shigella flexneri 2a strain 301, which is up to 717253 bp in total length. These deleted segments altogether contain 670 open reading frames (ORFs). Prediction of these ORFs indicates that there are 40% genes of unknown function. The other genes of definite functions encode metabolic enzymes, structure proteins, transcription regulatory factors and some elements correlated with horizontal transfer. Here we compare the complete genomic sequences of the two closely related species, which differ in pathogenic phenotype. To our knowledge, this not only reveals the difference of genomic sequence between the two important enteric pathogens for the first time, but also provides valuable clues to further researches in its process of physiological activity, pathogenesis and the evolution of enteric bacteria.
机译：在弗氏志贺氏菌2a菌株301及其近亲非致病性大肠杆菌K-12菌株MG1655之间进行比较基因组分析。结果表明，日本志贺氏菌2a株301不存在136个大于1000 bp的DNA片段，全长达717253 bp。这些删除的片段总共包含670个开放阅读框（ORF）。对这些ORF的预测表明，有40％的基因功能未知。其他具有确定功能的基因编码代谢酶，结构蛋白，转录调节因子以及与水平转移相关的某些元素。在这里，我们比较了两个密切相关物种的完整基因组序列，它们在致病表型方面有所不同。据我们所知，这不仅首次揭示了两种重要的肠道病原体之间的基因组序列差异，而且为进一步研究其生理活性，发病机理和肠道细菌的进化提供了有价值的线索。

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