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首页> 外文期刊>Chinese science bulletin >Icariin suppresses bone resorption activity of rabbit osteoclasts in vitro
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Icariin suppresses bone resorption activity of rabbit osteoclasts in vitro

机译：Icariin抑制兔破骨细胞的骨吸收活性

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摘要

The effect of icariin on the bone resorption activity of rabbit osteoctasts is assessed in vitro. Osteoclasts were isolated from Japanese white rabbits and cultured on plates with a sterilized bone slice in each well. After treatment with icariin at various concentrations, the bone resorption activity of osteoclasts was evaluated by examining pit areas, superoxide anion (~·O_2~-) generation, size and number of actin rings and intracellular calcium concentration [Ca~(2+)]_i. As revealed by these data, icariin elicited continuous decline of [Ca~(2+)]_i, making actin ring constricted and ~·O_2~- generation decreased. These events resulted in smaller and fewer pits which indicate suppressed bone resorption activity of rabbit osteoclasts by icariin.
机译：体外评估了二十碳素对兔骨碎骨的骨吸收活性的影响。从日本白兔中分离出破骨细胞，并在平板上培养，每个平板上均带有灭菌的骨切片。用不同浓度的番石榴素处理后，通过检查凹坑面积，超氧阴离子（〜·O_2〜-）生成，肌动蛋白环的大小和数量以及细胞内钙浓度[Ca〜（2+）]评估破骨细胞的骨吸收活性。 _一世。正如这些数据所揭示的那样，洋ari素引起[Ca〜（2 +）] _ i的持续下降，使肌动蛋白环收缩，〜·O_2〜-生成减少。这些事件导致较小和较少的凹坑，这表明二十碳素抑制了兔破骨细胞的骨吸收活性。

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