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首页> 外文期刊>Chinese science bulletin >Heat and hyposmotic stimulation increase in [Ca2+](i) by Ca2+ influx in rat synoviocytes
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Heat and hyposmotic stimulation increase in [Ca2+](i) by Ca2+ influx in rat synoviocytes

机译：Ca2 +流入大鼠滑膜细胞时，[Ca2 +]（i）的热和低渗刺激增加

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摘要

Rheumatoid arthritis (RA), which is marked by inflammatory synovitis, is a common, chronic autoimmune-disease, whose pathogenesis is complex and still unclear. In order to explore the effects of heat and hyposmotic stimuli on synoviocytes in rheumatoid arthritis, the changes of [Ca2+](i) induced by heat, hyposmotic and 4 alpha-PDD stimuli were observed in synoviocytes. [Ca2+](i) elevation induced by heat >= 28 degrees C, hyposmotic and 4 alpha-PDD stimuli is found to be positively relative to increasing temperature, decreasing osmolality and rising concentration of 4 alpha-PDD. Results show that there is reciprocity among these stimuli and desensitization, and that [Ca2+](i) elevation depends on Ca2+ influx, but not necessarily links to Ca2+ release from intracellular stores and voltage-dependent Ca2+ channel in synoviocytes. The above characteristics of Ca2+ influx are similar to those of TRPV4. A probable mechanism has been suggested that heat and hyposmotic stimulation might increase the level of [Ca2+](i) by activating the TRPV4-like channel and Ca2+ influx in the synoviocytes.
机译：类风湿关节炎（RA）以炎症性滑膜炎为特征，是一种常见的慢性自身免疫性疾病，其发病机理复杂且仍不清楚。为了探讨热和低渗刺激对类风湿关节炎滑膜细胞的影响，观察了滑膜细胞受热，低渗和4α-PDD刺激诱导的[Ca2 +]（i）的变化。发现热量> = 28摄氏度，低渗和4α-PDD刺激引起的[Ca2 +]（i）升高与温度升高，渗透压降低和4α-PDD浓度升高呈正相关。结果表明，这些刺激和脱敏之间存在互易性，并且[Ca2 +]（i）升高取决于Ca2 +的流入，但不一定与滑膜细胞中Ca2 +从细胞内储存的释放和电压依赖性Ca2 +通道有关。 Ca 2+流入的上述特征与TRPV4相似。已经提出了一种可能的机制，即热和低渗刺激可能通过激活滑膜细胞中的TRPV4样通道和Ca2 +流入而增加[Ca2 +]（i）的水平。

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