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首页> 外文期刊>Chemistry and Physics of Lipids >Polyion-induced aggregation of oppositely charged liposomes and charged colloidal particles: The many facets of complex formation in low-density colloidal systems
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Polyion-induced aggregation of oppositely charged liposomes and charged colloidal particles: The many facets of complex formation in low-density colloidal systems

机译：聚离子诱导的带相反电荷的脂质体和带电胶体颗粒的聚集：低密度胶体系统中复合物形成的许多方面

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This review focusses on recent developments in the experimental study of polyion-induced charged colloidal particle aggregation, with particular emphasis on the formation of cationic liposome clusters induced by the addition of anionic adsorbing polyions. These structures can be considered, under certain points of view, a new class of colloidal systems, with intriguing properties that opens interesting and promising new Opportunities in Various biotechnological applications. Lipidic structures of different morphologies and different Structural complexities interacting with oppositely charged polyions give rise to a rich variety of self-assembled structures that present various orders of hierarchy in the sense that, starting from a basic level, for example a lipid bilayer, they arrange themselves into superstructures as, for example, multilamellar stacks or liquid-crystalline structures. These Structures can be roughly divided into two classes according to the fact that the elementary structure, involved in building a more complex one, keeps or does riot keeps its basic arrangement. To the first one, belong those aggregates composed by single structures that maintain their integrity, for example. lipidic vesicles assembled together by an appropriate external agent. The second one encompasses structures that do riot resemble the ones of the original objects which form them, but, conversely, derive from a deep restructuring and rearrangement process. where the original morphology of the initial constitutive elements is completely lost. In this review, I will only briefly touch Oil higher level hierarchy structures and I will focus on the assembling processes involving preformed lipid bilayer vesicles that organize themselves into clusters, the process being induced by the adsorption of oppositely charged polyions. The scientific interest in polyion-induced liposome aggregates is two-fold. Oil the one hand, in soft-matter physics, they represent an interesting colloidal system, governed by a balance between long-range electrostatic repulsion and short-range attraction. resulting in relatively large, equilibrium Clusters, whose size and overall charge can be continuously tunable by simple environmental parameters. These structures present a variety of behaviors with a riot yet completely understood phenomenology. Oil the other hand, the resulting structures possess some peculiar properties that justify their employment as drug delivery systems. Bio-compatibility, stability and ability to deliver various bio-active molecules and, moreover, their environmental responsiveness make liposome-based clusters a versatile carrier, with possibility of efficient targeting to different organs and tissues. Among the different structures made possible by the aggregating mechanism (cationic particles stuck together by anionic polyions or conversely anionic particles stuck together by cationic polyions). I will review the main experimental evidences for the existence of cationic liposome clusters. Especial attention is paid to our own work, mainly aimed at the characterization of these novel structures from a physical point of view. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
机译：这篇综述着重于聚离子诱导的带电胶体粒子聚集的实验研究中的最新进展，特别着重于通过添加阴离子吸附聚离子诱导的阳离子脂质体簇的形成。从某些角度来看，可以认为这些结构是一类新型的胶体系统，其迷人的特性为各种生物技术应用打开了有趣而有希望的新机遇。不同形态和不同结构复杂性的脂质结构与带相反电荷的聚离子相互作用，产生了各种各样的自组装结构，从基本水平（例如脂质双层）开始，它们排列着不同层次的顺序本身成为上层结构，例如多层堆栈或液晶结构。根据构成一个更复杂的基本结构可以保持或确实保持其基本安排这一事实，可以将这些结构大致分为两类。例如，第一个属于那些由单个结构组成的聚合体，这些结构可保持其完整性。脂质囊泡由适当的外部试剂组装在一起。第二个结构包含的暴动结构与形成它们的原始对象很像，但相反，它们是从深层的重组和重新安排过程中衍生而来的。最初的本构元素的原始形态完全消失了。在本文中，我将仅简要介绍Oil的更高层次结构，重点关注组装过程，这些过程涉及预先形成的脂质双层囊泡，这些囊泡将自身组织成簇，该过程是由带相反电荷的聚离子的吸附引起的。对聚离子诱导的脂质体聚集体的科学兴趣是双重的。一方面，在软物质物理学中，它们代表了一种有趣的胶体系统，受长距离静电斥力和短距离吸引力之间的平衡支配。产生相对较大的平衡簇，其大小和总电荷可以通过简单的环境参数连续调整。这些结构表现出各种行为，并具有暴乱但尚未完全理解的现象学。另一方面，所得到的结构具有一些独特的特性，这些特性证明了它们被用作药物输送系统的合理性。生物相容性，稳定性和传递各种生物活性分子的能力，以及它们对环境的响应能力，使得脂质体簇成为通用的载体，并可能有效地靶向不同的器官和组织。在不同的结构中，通过聚集机制成为可能（阳离子颗粒通过阴离子聚离子粘在一起，或者相反，阴离子颗粒通过阳离子聚离子粘在一起）。我将回顾阳离子脂质体簇存在的主要实验证据。特别注意我们自己的工作，主要是从物理角度对这些新颖结构进行表征。 （C）2008 Elsevier Ireland Ltd.保留所有权利。

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