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首页> 外文期刊>Chinese science bulletin >Trace element characteristics of a Gorham-Stout Syndrome sufferer
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Trace element characteristics of a Gorham-Stout Syndrome sufferer

机译：Gorham-Stout综合征患者的微量元素特征

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摘要

Gorham-Stout Syndrome (GSS) is an infrequent and mysterious bone disease characterized by massive bone dissolving or even disappearing due to an unknown pathogeny. It is quite different from the Itai-itai disease and osteoporosis. In 2001, an 8-year-old boy from a small town in Xinjiang was found to get GSS disease. Some parts of his bones vanished without any external force. Results showed that the concentrations of Cd and Cu, especially Na and K in his hair were far higher than those of the healthy people, and the concentration of Cd was 2 times that of the reference while those of Cr and Zn were insufficient for health. The ratio of K/Na was also higher than that of healthy group. Four different ratios revealed weak bone growth potential and strong bone breakage occurred simultaneously in the GSS sufferer's skeletal system. It might be the synergistic effect of the trace elements leading to the baffling syndrome. Further investigation demonstrated that the trace elements can cause a series of diseases, including GSS disease and a typical rheumatoid arthritis (ARA). Epidemiological investigation also proved that there were about 25% of the inhabitants in the town suffered from an ARA. All of these data implied there was significant relationship among Gorham-Stout Syndrome, ARA and prolapse of lumbar intervertebral disc.
机译：Gorham-Stout综合征（GSS）是一种罕见且神秘的骨病，其特征在于由于未知的病因，大量骨溶解或消失。它与Itai-itai疾病和骨质疏松症完全不同。 2001年，新疆一个小镇的8岁男孩被发现患有GSS疾病。他的骨头的某些部分消失了，没有任何外力。结果表明，头发中的Cd和Cu浓度，尤其是Na和K远远高于健康人，Cd浓度是参考浓度的2倍，而Cr和Zn不足以保证健康。钾/钠比值也高于健康组。四个不同的比率显示，GSS患者的骨骼系统中同时发生了弱骨生长潜力和强骨断裂。微量元素的协同​​作用可能导致莫名其妙的综合症。进一步的研究表明，微量元素可引起一系列疾病，包括GSS疾病和典型的类风湿关节炎（ARA）。流行病学调查还证明，该镇约有25％的居民患有ARA。所有这些数据表明，戈拉姆-斯托特综合征，ARA与腰椎间盘突出症之间存在显着相关性。

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