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首页> 外文期刊>Haemophilia: the official journal of the World Federation of Hemophilia >Effects of moderate-intensity physical exercise on pharmacokinetics of factor VIII and von Willebrand factor in young adults with severe haemophilia A: a pilot study
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Effects of moderate-intensity physical exercise on pharmacokinetics of factor VIII and von Willebrand factor in young adults with severe haemophilia A: a pilot study

机译：中等强度体育锻炼对重度血友病青壮年年轻人中VIII因子和von Willebrand因子药代动力学的影响

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Introduction: In persons with severe haemophilia A (pwshA), infused factor VIII (FVIII) half-life can vary according to such determinants as blood group, von Willebrand factor (VWF) level or age; however, FVIII pharmacokinetics (PK) has not been well studied in pwshA during exercise. Aim: To investigate FVIII PK in pwshA performing moderate-intensity aerobic exercise. Methods: Twelve young-adult pwshA with the intron-22 inversion mutation, on relatively low-dose FVIII prophylaxis regimens, and relatively good musculoskeletal status were recruited. Abbreviated PK of FVIII activity and von Willebrand factor antigen (VWF: Ag) level were compared - during rest, and with 60-min exercise (2 x 15 min each of moderate-intensity stationary cycling and treadmill walking). During rest and exercise visits, a baseline blood specimen was drawn, routine prophylaxis FVIII infused; then six blood specimens were taken over the following 24 h. Results: For all subjects, mean half-life of infused FVIII did not change significantly with exercise vs. at rest (577 +/- 190 vs. 614 +/- 163 min; P = 0.4131). VWF: Ag rose transiently by 40-50% for 6-8 h with exercise (P < 0.01), particularly in non-O blood group subjects. No musculoskeletal bleeds occurred during the study. Conclusion: Four x 15 min of moderate-intensity aerobic exercise increased VWF: Ag levels for 6-8 h, and showed no evidence of accelerated FVIII clearance or of musculoskeletal bleeding in these young-adult pwshA with relatively good musculoskeletal status, on relatively low-dose FVIII prophylaxis regimens. However, O blood group impact would merit larger studies, with longer durations of similar or more vigorous exercise intensities.
机译：简介：在患有严重A型血友病（pwshA）的人中，注入的VIII因子（FVIII）的半衰期可能会根据血型，von Willebrand因子（VWF）水平或年龄等决定因素而有所不同。但是，尚未对运动过程中的pwshA中的FVIII药代动力学（PK）进行很好的研究。目的：研究进行中等强度有氧运动的pwshA中的FVIII PK。方法：招募了十二个具有内含子22倒位突变的年轻pwshA，采用相对低剂量的FVIII预防方案，并具有相对较好的肌肉骨骼状态。比较了FVIII活性的缩写PK和von Willebrand因子抗原（VWF：Ag）的水平-在休息期间，以及60分钟的运动（中等强度的固定自行车和跑步机步行各2 x 15分钟）。在休息和运动拜访期间，抽取基线血液样本，并注入常规预防性FVIII。然后在接下来的24小时内采集了六个血液样本。结果：对于所有受试者，在运动与休息时相比，输注FVIII的平均半衰期均无明显变化（577 +/- 190 vs. 614 +/- 163 min; P = 0.4131）。 VWF：在运动6-8小时后，Ag短暂升高40-50％（P <0.01），尤其是在非O血型受试者中。在研究过程中未发生肌肉骨骼出血。结论：在中等强度的有氧运动中，每4 x 15分钟可使VWF：Ag水平升高6-8小时，并且在这些肌肉骨骼状态相对较好，相对较低的年轻pwshA中，没有显示加速的FVIII清除或肌肉骨骼出血的迹象。剂量的FVIII预防方案。但是，O血型的影响值得进行更大的研究，而持续时间更长或更长时间或更相似或更剧烈的运动强度。

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