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首页> 外文期刊>Chemistry and Physics of Lipids >Lateral organization, bilayer asymmetry, and inter-leaflet coupling of biological membranes
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Lateral organization, bilayer asymmetry, and inter-leaflet coupling of biological membranes

机译：生物膜的横向组织，双层不对称和叶间偶联

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摘要

Understanding of cell membrane organization has evolved significantly from the classic fluid mosaic model. It is now recognized that biological membranes are highly organized structures, with differences in lipid compositions between inner and outer leaflets and in lateral structures within the bilayer plane, known as lipid rafts. These organizing principles are important for protein localization and function as well as cellular signaling. However, the mechanisms and biophysical basis of lipid raft formation, structure, dynamics and function are not clearly understood. One key question, which we focus on in this review, is how lateral organization and leaflet compositional asymmetry are coupled. Detailed information elucidating this question has been sparse because of the small size and transient nature of rafts and the experimental challenges in constructing asymmetric bilayers. Resolving this mystery will require advances in both experimentation and modeling. We discuss here the preparation of model systems along with experimental and computational approaches that have been applied in efforts to address this key question in membrane biology. We seek to place recent and future advances in experimental and computational techniques in context, providing insight into in-plane and transverse organization of biological membranes. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
机译：对细胞膜组织的了解已从经典的流体镶嵌模型显着发展。现在已经认识到，生物膜是高度组织化的结构，在内部和外部小叶之间的脂质组成以及在双层平面内的侧向结构中具有不同的脂质筏。这些组织原理对于蛋白质定位和功能以及细胞信号传导非常重要。然而，尚不清楚脂质筏的形成，结构，动力学和功能的机理和生物物理基础。在这篇综述中，我们重点关注的一个关键问题是横向组织和小叶组成不对称如何耦合。由于筏的尺寸小，瞬态特性以及构造不对称双层的实验挑战，阐明这一问题的详细信息很少。解决这个谜题需要在实验和建模上都取得进步。我们在这里讨论模型系统的准备以及实验和计算方法，这些方法已经用于解决膜生物学中的这一关键问题。我们力求将实验和计算技术的最新和未来进展放在上下文中，以提供对生物膜的平面和横向组织的了解。 （C）2015 Elsevier Ireland Ltd.保留所有权利。

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