Interaction of ferulic acid derivatives with human erythrocytes monitored by pulse field gradient NMR diffusion and NMR relaxation studies

Anselmi C; Bernardi F; Centini M; Gaggelli E; Gaggelli N; Valensin D; Valensin G

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Interaction of ferulic acid derivatives with human erythrocytes monitored by pulse field gradient NMR diffusion and NMR relaxation studies

机译：通过脉冲场梯度NMR扩散和NMR弛豫研究监测阿魏酸衍生物与人红细胞的相互作用

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Ferulic acid (Fer), a natural anti, oxidant and chemo-protector, is able to suppress experimental carcinogenesis in the forestomach, lungs, skin, tongue and colon. Several Fer derivatives have been suggested as promising candidates for cancer prevention, being the biological activity related also to the capacity of partitioning between aqueous and lipid phases. In the present work, pulsed field gradient (PFG) NMR diffusion measurement and NMR relaxation rates have been adopted for investigating the interaction of three Fer derivatives (Fer-C11, Fer-C12 and Fer-C13) with human erythrocytes. Binding to the erythrocyte membrane has been shown for all derivatives, which displayed a similar interaction mode such that the aromatic moiety and the terminal part of the alkyl chain were the most affected. Quantitative analysis of the diffusion coefficients was used to show that Fer-C12 and Fer-C13 display higher affinity for the cell membrane when compared with Fer-C11. These findings agree with the higher anti-oxidant activity of the two derivatives. (c) 2005 Published by Elsevier Ireland Ltd.

机译：阿魏酸（Fer）是一种天然抗氧化剂，氧化剂和化学保护剂，能够抑制前胃，肺，皮肤，舌头和结肠中的实验性致癌作用。已经提出了几种Fer衍生物作为预防癌症的有前途的候选物，因为其生物活性还与水相和脂质相之间的分配能力有关。在目前的工作中，已采用脉冲场梯度（PFG）NMR扩散测量和NMR弛豫率来研究三种Fer衍生物（Fer-C11，Fer-C12和Fer-C13）与人红细胞的相互作用。对于所有衍生物，已经显示出与红细胞膜的结合，这些衍生物表现出相似的相互作用模式，使得芳族部分和烷基链的末端部分受影响最大。扩散系数的定量分析显示，与Fer-C11相比，Fer-C12和Fer-C13对细胞膜具有更高的亲和力。这些发现与两种衍生物的更高的抗氧化活性一致。（c）2005由爱思唯尔爱尔兰有限公司出版。

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《Chemistry and Physics of Lipids》 |2005年第2期|共9页
作者
Anselmi C; Bernardi F; Centini M; Gaggelli E; Gaggelli N; Valensin D; Valensin G;
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正文语种 eng
中图分类生物化学;
关键词
ferulic acid derivatives; PFG NMR; relaxation; erythrocytes; NUCLEAR-MAGNETIC-RESONANCE; ANTIOXIDANT ACTIVITY; SELF-DIFFUSION; PEPTIDE AGGREGATION; COUNTERION BINDING; AFFINITY NMR; EDITED NMR; SPECTROSCOPY; ASSOCIATION; TRANSPORT;

机译：阿魏酸衍生物;PFG NMR;松弛;红细胞;核磁共振;抗氧化剂活性;自扩散;肽聚集;抗衡结合;亲和力NMR;编辑的NMR;光谱学;结合;运输;

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1. Interaction of ferulic acid derivatives with human erythrocytes monitored by pulse field gradient NMR diffusion and NMR relaxation studies [J] . Anselmi C, Bernardi F, Centini M, Chemistry and Physics of Lipids . 2005,第2期

机译：通过脉冲场梯度NMR扩散和NMR弛豫研究监测阿魏酸衍生物与人红细胞的相互作用
2. EFFECTS OF CHOLESTEROL ON TRANSMEMBRANE WATER DIFFUSION IN HUMAN ERYTHROCYTES MEASURED USING PULSED FIELD GRADIENT NMR [J] . Waldeck AR., Sullivan DR., Kuchel PW., Biophysical Chemistry: An International Journal Devoted to the Physical Chemistry of Biological Phenomena . 1995,第3期

机译：脉冲场梯度NMR测定胆固醇对人红细胞中跨膜水扩散的影响
3. Diffusional behavior of amino acids in solid-phase reaction field as studied by H-1 pulsed-field-gradient spin-echo NMR method [J] . Yamane Y., Kobayashi M., Kimura H., Polymer: The International Journal for the Science and Technology of Polymers . 2002,第6期

机译：H-1脉冲场梯度自旋回波NMR法研究固相反应场中氨基酸的扩散行为
4. The Intra/Inter-Molecular Interactions of NOM Components: A Study of Self-Assembly Using Small Angle Neutron Scattering and Pulsed- Field Gradient NMR [C] . C. Johnson-Edler, G. Chilom, L. Hoffman The Meeting of the International Humic Substances Society . 2015

机译：NOM组分的内/间分子相互作用：使用小角度中子散射和脉冲场梯度NMR的自组装研究
5. Development and application of high-field, high-gradient pulsed field gradient NMR for studies of diffusion behavior of lipids in model membranes . [D] . Sanders, Monica Danielle. 2009

机译：高场，高梯度脉冲场梯度NMR的开发和应用，用于研究脂质在模型膜中的扩散行为。
6. Studies of the binding and structure of adrenocorticotropin peptides in membrane mimics by NMR spectroscopy and pulsed-field gradient diffusion. [O] . X Gao, T C Wong 1998

机译：通过NMR光谱和脉冲场梯度扩散研究膜模拟物中肾上腺皮质激素肽的结合和结构。
7. Restricted Diffusion of an 19F-Labelled Organic Acid in Human Erythrocytes Analyzed by 19F Pulsed Field Gradient NMR. [O] . Yoshiteru SEO, Ute AMMER, Toru ISHIKAWA, 1995

机译：在由19F脉冲场梯度NMR分析的人红细胞中限制19F标记有机酸的扩散。

Interaction of ferulic acid derivatives with human erythrocytes monitored by pulse field gradient NMR diffusion and NMR relaxation studies

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