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Common threads in atrial fibrillation and heart failure

机译:心房颤动和心力衰竭的共同点

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摘要

The prevalence of both chronic heart failure and atrial fibrillation is increasing as a result of systemic multimorbid risk and improved therapy of acute heart disease. Current treatment options are unsatisfactory especially regarding antiarrhythmic drugs. We propose that a systems biology approach to increase understanding of cardiac arrhythmias offers the best immediate way forward. Such an approach would be based on an accumulation of large clinical datasets, and application of next-generation sequencing in conjunction with selected experimental and computer-based models. Such an approach would in turn facilitate the development and targeted application of currently available and novel therapeutic approaches.
机译:由于系统性多病态风险和对急性心脏病的改良治疗,慢性心力衰竭和心房颤动的患病率正在增加。当前的治疗选择不能令人满意,尤其是在抗心律不齐药物方面。我们建议采用一种系统生物学的方法来增加对心律不齐的了解,这是最好的直接方法。这种方法将基于大量临床数据集的积累,以及结合选定的实验模型和基于计算机的模型进行下一代测序的应用。这样的方法将反过来促进当前可用的和新颖的治疗方法的开发和有针对性的应用。

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