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首页> 外文期刊>Heart and Lung: The Journal of Critical Care >Deleterious impact of mild anemia on survival of young adult patients (age 45 +/- 14 years) with idiopathic dilated cardiomyopathy: data from the Trieste Cardiomyopathies Registry.
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Deleterious impact of mild anemia on survival of young adult patients (age 45 +/- 14 years) with idiopathic dilated cardiomyopathy: data from the Trieste Cardiomyopathies Registry.

机译：轻度贫血对患有特发性扩张型心肌病的年轻成人患者（45 +/- 14岁）的生存的有害影响：Trieste心肌病登记处的数据。

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OBJECTIVE: The study objective was to evaluate the impact of anemia on a large population of young patients with idiopathic dilated cardiomyopathy (DCM) who were receiving optimal medical treatment. METHODS: The data of 491 patients with DCM who were enlisted in the Trieste Heart Muscle Disease Registry were analyzed. Anemia was defined as hemoglobin less than 13 g/dL for male patients and less than 12 g/dL for female patients. RESULTS: At baseline, 13% of our patients were anemic. During the follow-up of 134 +/- 56 months, 144 patients died or underwent heart transplantation: 36.5% anemic patients and 28% non-anemic patients (P = .05). Anemia present at baseline was an independent predictor of outcome (hazard ratio = 1.85, P = .014). Serial hemoglobin determinations during the entire follow-up were available in 122 of 428 patients without anemia at baseline. The impact of new-onset anemia was analyzed in this cohort of patients. Forty-seven patients (39%) developed anemia during follow-up. The new onset of anemia was an independent predictor of poor outcome (hazard ratio = 2.85, P = .02). CONCLUSION: The presence or development of mild anemia in young patients with optimally treated idiopathic DCM is frequent and associated with a worse outcome.
机译：目的：本研究的目的是评估贫血对大量接受最佳治疗的特发性扩张型心肌病（DCM）的年轻患者的影响。方法：分析了在的里雅斯特心脏疾病登记处登记的491例DCM患者的数据。贫血定义为男性患者血红蛋白低于13 g / dL，女性患者血红蛋白低于12 g / dL。结果：在基线时，我们13％的患者贫血。在134 +/- 56个月的随访期间，有144例患者死亡或接受了心脏移植：36.5％的贫血患者和28％的非贫血患者（P = .05）。基线时出现的贫血是结果的独立预测因素（危险比= 1.85，P = .014）。在428名无贫血的基线患者中，有122名患者在整个随访过程中进行了血红蛋白的连续测定。在这一组患者中分析了新发性贫血的影响。 47位患者（39％）在随访期间发生了贫血。贫血的新发作是不良预后的独立预测因子（危险比= 2.85，P = .02）。结论：患有特发性DCM的年轻患者中轻度贫血的发生或发展是常见的，并伴有较差的预后。

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