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首页> 外文期刊>Heart and vessels: An international journal >Effects of arterial blood flow on walls of the abdominal aorta: distributions of wall shear stress and oscillatory shear index determined by phase-contrast magnetic resonance imaging
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Effects of arterial blood flow on walls of the abdominal aorta: distributions of wall shear stress and oscillatory shear index determined by phase-contrast magnetic resonance imaging

机译：动脉血流对腹主动脉壁的影响：通过相差磁共振成像确定壁切应力和振荡剪切指数的分布

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Although abdominal aortic aneurysms (AAAs) occur mostly inferior to the renal artery, the mechanism of the development of AAA in relation to its specific location is not yet clearly understood. The objective of this study was to evaluate the hypothesis that even healthy volunteers may manifest specific flow characteristics of blood flow and alter wall shear or oscillatory shear stress in the areas where AAAs commonly develop. Eight healthy male volunteers were enrolled in this prospective study, aged from 24 to 27. Phase-contrast magnetic resonance imaging (MRI) was performed with electrocardiographic triggering. Flow-sensitive four-dimensional MR imaging of the abdominal aorta, with three-directional velocity encoding, including simple morphological image acquisition, was performed. Information on specific locations on the aortic wall was applied to the flow encodes to calculate wall shear stress (WSS) and oscillatory shear index (OSI). While time-framed WSS showed the highest peak of 1.14 +/- A 0.25 Pa in the juxtaposition of the renal artery, the WSS plateaued to 0.61 Pa at the anterior wall of the abdominal aorta. The OSI peaked distal to the renal arteries at the posterior wall of the abdominal aorta of 0.249 +/- A 0.148, and was constantly elevated in the whole abdominal aorta at more than 0.14. All subjects were found to have elevated OSI in regions where AAAs commonly occur. These findings indicate that areas of constant peaked oscillatory shear stress in the infra-renal aorta may be one of the factors that lead to morphological changes over time, even in healthy individuals.
机译：尽管腹主动脉瘤（AAAs）大多位于肾动脉以下，但尚未明确了解AAA与特定位置相关的发生机制。这项研究的目的是评估这样一种假设，即即使健康的志愿者也可能会表现出特定的血流特征，并改变AAA易发地区的壁切或振荡切应力。八名健康的男性志愿者参加了这项前瞻性研究，年龄从24岁到27岁。相差磁共振成像（MRI）是通过心电图触发进行的。对腹主动脉进行流量敏感的三维MR成像，并进行三方向速度编码，包括简单的形态学图像采集。将有关主动脉壁上特定位置的信息应用于流编码，以计算壁切应力（WSS）和振荡剪切指数（OSI）。有时间限制的WSS在并置的肾动脉中显示出1.14 +/- A 0.25 Pa的最高峰，而WSS在腹主动脉的前壁处稳定在0.61 Pa。 OSI在腹主动脉后壁的肾动脉远端达到峰值0.249 +/- A 0.148，并在整个腹主动脉中不断升高，超过0.14。发现所有受试者在通常发生AAA的地区OSI升高。这些发现表明，即使在健康个体中，肾主动脉中恒定的峰值振荡剪切应力区域也可能是导致形态随时间变化的因素之一。

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