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Identification of active chemotherapy regimens in advanced biliary tract carcinoma: a review of chemotherapy trials in the past two decades

机译：晚期胆道癌的有效化疗方案的确定：过去二十年中的化疗试验回顾

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摘要

Biliary tract carcinoma is a rare malignancy. We performed a comprehensive analysis of published prospective clinical trials in advanced biliary tract carcinoma in an attempt to identify active regimens in this setting. We searched PubMed and abstracts presented at the American Society of Clinical Oncology, Gastrointestinal Cancer Symposium, European Society of Medical Oncology and European Cancer Organization conferences for clinical trials in this disease. We found 83 trials. The effect of gemcitabine on overall survival benefit showed a strong trend (p = 0.014) and an improvement in progression-free survival (p = 0.003). Gemcitabine-based regimens containing 5-fluorouracil showed a trend toward an improved overall survival (p = 0.047) relative to platinum agents. Our findings support gemcitabine as the chemotherapy backbone for the treatment of patients with cholangiocarcinoma. Gemcitabine plus 5-fluorouracil combinations warrant further investigations.
机译：胆道癌是一种罕见的恶性肿瘤。我们对已发表的晚期胆道癌前瞻性临床试验进行了全面分析，以试图确定这种情况下的有效治疗方案。我们检索了在美国临床肿瘤学会，胃肠道癌专题讨论会，欧洲医学肿瘤学会和欧洲癌症组织会议上发表的PubMed和摘要，以进行该疾病的临床试验。我们找到83个试验。吉西他滨对总体生存获益的影响显示出强劲的趋势（p = 0.014）和无进展生存期的改善（p = 0.003）。相对于铂类药物，含5-氟尿嘧啶的吉西他滨为基础的治疗方案显示总体生存率有改善的趋势（p = 0.047）。我们的发现支持吉西他滨作为治疗胆管癌患者的化学疗法的骨干。吉西他滨加5-氟尿嘧啶的组合值得进一步研究。

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