...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Hepato-gastroenterology. >Effect of Helicobacter pylori eradication on blood ammonia levels in cirrhotic patients: A systematic review
【24h】

Effect of Helicobacter pylori eradication on blood ammonia levels in cirrhotic patients: A systematic review

机译：根除幽门螺杆菌对肝硬化患者血氨水平的影响：系统评价

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background/Aims: The effect of Helicobacter pylori (H. pylori) eradication on blood ammonia levels in cirrhotic patients is still controversial. We aimed to clarify this effect by performing a quantitative meta-analysis of published studies. Methodology: We searched PubMed, EMBASE and Cochrane library for studies which explored the effect of H. pylori eradication on blood ammonia levels in cirrhotic patients before March 2012. A random-effects meta-analysis was performed. Results: Nine studies (five non-randomized control studies and four before-after studies) involved in 699 cirrhotic patients who were given H. pylori eradication eligible to our analysis. The before-after studies suggested that H. pylori eradication can significantly reduce the blood ammonia levels in cirrhotic patients (SMD=0.32, 95%CI=0.11-0.53, I2=39.6%). After included five non-randomized control studies, the overall results suggested that H. pylori eradication can not reduce the blood ammonia levels in cirrhotic patients (SMD=-0.36, 95% CI=-0.83-0.11) and with significant heterogeneity (I2=89.3%). Subgroup analysis suggested that the no effect was found between Caucasian and Asian ethnicity and between cirrhotic patients with Child-Pugh class B/C 70% and 70%. Conclusions: The effect of eradication of H. pylori on blood ammonia levels in cirrhotic patients is mainly caused by the non-specific effect of antibiotics regardless of patients' ethnicity and impairment of liver function. However, due to limited studies available and low methodological quality that marked by high risks of bias, our study should be interpreted cautiously.
机译：背景/目的：根除幽门螺杆菌（H. pylori）对肝硬化患者血氨水平的影响仍存在争议。我们旨在通过对已发表研究进行定量荟萃分析来阐明这种影响。方法：我们在PubMed，EMBASE和Cochrane库中进行了研究，以探讨根除幽门螺杆菌对肝硬化患者血氨水平的影响。进行了一项随机效应荟萃分析。结果：9项研究（5项非随机对照研究和4项前后研究）涉及699例接受根除幽门螺杆菌的肝硬化患者，符合我们的分析要求。前后研究表明，根除幽门螺杆菌可以显着降低肝硬化患者的血氨水平（SMD = 0.32，95％CI = 0.11-0.53，I2 = 39.6％）。在纳入五项非随机对照研究后，总体结果表明，根除幽门螺杆菌不能降低肝硬化患者的血氨水平（SMD = -0.36，95％CI = -0.83-0.11），并且异质性很强（I2 = 89.3％）。亚组分析表明，在白人和亚洲种族之间以及在Child-Pugh B / C级<70％和> 70％的肝硬化患者之间没有发现影响。结论：根除幽门螺杆菌对肝硬化患者血氨水平的影响主要是由于抗生素的非特异性作用引起的，而与患者的种族和肝功能损害无关。但是，由于可用研究有限且方法学质量低下（以偏见风险较高为特征），因此应谨慎解释我们的研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号