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首页> 外文期刊>Hepato-gastroenterology. >Clinical characteristics and prognostic indicators of drug-induced fulminant hepatic failure.
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Clinical characteristics and prognostic indicators of drug-induced fulminant hepatic failure.

机译：药物性暴发性肝衰竭的临床特征和预后指标。

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BACKGROUND/AIMS: In most cases of drug-induced liver injury, it is difficult to diagnose whether these cases would progress to fulminant hepatic failure. We investigated the characteristics of non-viral and suspiciously drug-induced fulminant hepatic failure by comparing clinical data between cases that progressed and those that did not progress to fulminant hepatic failure. METHODOLOGY: Ninety-five cases of suspicious drug-induced liver injury including 22 cases that had been treated at our hospital, and subsequently progressed to fulminant hepatic failure were involved in this study. We investigated the characteristics of drug-induced fulminant hepatic failure by a comparison of non-fulminant and fulminant cases, and simultaneously of survivors and fatal cases in the group of fulminant cases. RESULTS: Many of the clinical variables were significantly deteriorated in fulminant cases. The latent period, which means the duration of drug administration, correlated with the severity of drug-induced liver injury including fulminant hepatic failure. Suspicious cases of drug-induced liver injury where the bilirubin level at the time of definite diagnosis stayed over 13 mg/dL for more than one month were likely to progress to fulminant hepatic failure. CONCLUSIONS: Our results suggest that the latent period and the peak level of total bilirubin would be prognostic factors for the severity of drug-induced fulminant hepatic failure. Early preparation of liver transplantation should be recommended by referring these characteristics.
机译：背景/目的：在大多数药物性肝损伤病例中，很难诊断这些病例是否会发展为暴发性肝衰竭。我们通过比较进展中和未进展为暴发性肝衰竭的病例之间的临床数据，调查了非病毒性和可疑药物诱发的暴发性肝衰竭的特征。方法：本研究涉及95例可疑药物性肝损伤，其中22例在我院接受治疗，随后发展为暴发性肝衰竭。我们通过比较非暴发性病例和暴发性病例，以及暴发病例组中幸存者和致命病例的比较，调查了药物诱发的暴发性肝衰竭的特征。结果：暴发病例中许多临床变量均明显恶化。潜伏期，即给药的持续时间，与药物诱发的肝损伤（包括暴发性肝衰竭）的严重程度相关。在可疑的药物性肝损伤病例中，明确诊断时胆红素水平持续超过13 mg / dL超过一个月以上，可能会发展为暴发性肝衰竭。结论：我们的结果表明潜伏期和总胆红素水平的峰值将是药物性暴发性肝衰竭严重程度的预后因素。建议通过参考这些特征尽早准备肝移植。

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