• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Hepato-gastroenterology. >Clinical significance of plasma D-dimer levels and serum VEGF levels in patients with hepatocellular carcinoma.
【24h】

Clinical significance of plasma D-dimer levels and serum VEGF levels in patients with hepatocellular carcinoma.

机译：肝细胞癌患者血浆D-二聚体水平和血清VEGF水平的临床意义。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND/AIMS: Angiogenesis and coagulation system activation are associated with tumor growth and metastasis. Vascular endothelial growth factor (VEGF) has been reported to play a major role in tumor angiogenesis. The elevation of plasma D-dimer level indicates the activation of coagulation and fibrinolysis. The purpose of this study was to: (a) evaluate the correlation between serum VEGF and plasma D-dimer level; (b) analyze the clinical features that might affect the VEGF and D-dimer levels in patients with hepatocellular carcinoma. METHODOLOGY: Twenty patients with hepatocellular carcinoma were included prior to treatment. Serum VEGF levels were measured by enzyme-linked immunosorbent assay. Plasma D-dimer levels were measured by quantitative latex microparticle enhanced turbidimetric immunoassay. RESULTS: The presence of a high plasma D-dimer level was found to be correlated with the presence of central necrosis, higher Child's grade, advanced TNM stage, and the presence of portal vein thrombosis when plasma D-dimer levels were compared between different clinicopathologic groups. Tumors larger than 2 cm in diameter had higher median serum VEGF levels than tumors less than 2cm in diameter. No correlation was found between plasma D-dimer level and serum VEGF level in hepatocellular carcinoma patients (r=0.126, p=0.598). CONCLUSIONS: No correlation was found between the plasma D-dimer level and the serum VEGF level in hepatocellular carcinoma patients. The plasma D-dimer level appeared to reflect the tumor stage and vascular invasion of hepatocellular carcinoma. Serum VEGF level in hepatocellular carcinoma patients showed a positive correlation with tumor size.
机译：背景/目的：血管生成和凝血系统的激活与肿瘤的生长和转移有关。据报道，血管内皮生长因子（VEGF）在肿瘤血管生成中起主要作用。血浆D-二聚体水平的升高表明凝血和纤维蛋白溶解的激活。这项研究的目的是：（a）评估血清VEGF与血浆D-二聚体水平之间的相关性; （b）分析可能影响肝细胞癌患者VEGF和D-二聚体水平的临床特征。方法：治疗前纳入了20例肝细胞癌患者。通过酶联免疫吸附测定法测量血清VEGF水平。血浆D-二聚体水平通过定量乳胶微粒增强比浊免疫测定法测量。结果：当比较不同临床病理学之间的血浆D-二聚体水平时，发现血浆D-二聚体水平高与中央坏死的存在，Child's分级较高，TNM晚期分期以及门静脉血栓形成有关组。直径大于2 cm的肿瘤的中位血清VEGF水平高于直径小于2 cm的肿瘤。肝细胞癌患者血浆D-二聚体水平与血清​​VEGF水平无相关性（r = 0.126，p = 0.598）。结论：肝细胞癌患者血浆D-二聚体水平与血清​​VEGF水平无相关性。血浆D-二聚体水平似乎反映了肝细胞癌的肿瘤分期和血管浸润。肝细胞癌患者血清VEGF水平与肿瘤大小呈正相关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号