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首页> 外文期刊>Hepato-gastroenterology. >13CO2 excretion in breath of normal subjects and cirrhotic patients after 13C-aminopyrine oral load. Comparison with MEGX test in functional differentiation between chronic hepatitis and liver cirrhosis.
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13CO2 excretion in breath of normal subjects and cirrhotic patients after 13C-aminopyrine oral load. Comparison with MEGX test in functional differentiation between chronic hepatitis and liver cirrhosis.

机译：正常受试者和肝硬化患者经13C-氨基比林口服后呼吸中的13CO2排泄。与MEGX检验在慢性肝炎和肝硬化之间的功能分化方面的比较。

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BACKGROUND/AIMS: Liver function can be evaluated using 13C breath tests that explore liver Cytochrome P450 activity. Aminopyrine is one of the first compounds used in liver function testing. Lidocaine metabolism to monoethylglycinexylidide is also a valid tool to assess liver function. Although liver Cytochrome P450 metabolizes both compounds, lidocaine metabolism is flow-dependent while aminopyrine metabolism does not depend on liver blood flow. METHODOLOGY: The 1st part of the study evaluated the appearance and disappearance rate of 13CO2 in the breath of both normal subjects and in cirrhotic patients, so as to establish optimal sampling times and to evaluate the amount of time needed before performing a subsequent breath test. The 2nd part of the study compared the aminopyrine breath test with the monoethylglycinexylidide test in patients with chronic hepatitis or cirrhosis. RESULTS: Complete 13CO2 disappearance was recorded 24 hours after the test in normal subjects, while it took 3 days to disappear from the breath of cirrhotic patients. Breath sampling at 60, 120 and 180 min were equally valid in differentiating chronic hepatitis from cirrhosis. The aminopyrine breath test and monoethylglycinexylidide test showed a good yet not close correlation. CONCLUSIONS: This study showed that in cirrhotic patients a 13C breath test can be performed 3 days after the previous one. In chronic hepatitis and cirrhotic patients, the aminopyrine breath test and the monoethylglycinexylidide test evaluated similar, but not identical, hepatic subfunctions, suggesting that multiple 13C breath test using different substrates could explore liver function better.
机译：背景/目的：可以使用探索肝脏细胞色素P450活性的13C呼气试验来评估肝功能。氨基比林是肝功能测试中使用的首批化合物之一。利多卡因代谢成单乙基甘氨酰二糖也是评估肝功能的有效工具。尽管肝脏细胞色素P450代谢这两种化合物，利多卡因的代谢是血流依赖性的，而氨基比林的代谢并不取决于肝血流量。方法：研究的第一部分评估正常受试者和肝硬化患者的呼吸中13CO2的出现和消失率，以便确定最佳采样时间并评估进行后续呼吸测试之前需要的时间。研究的第二部分比较了慢性慢性肝炎或肝硬化患者的氨基比林呼气试验和单乙基甘氨糖苷试验。结果：正常受试者在测试后24小时记录了13CO2的完全消失，而肝硬化患者的呼吸需要3天才能消失。在60、120和180分钟时进行的呼吸采样对区分慢性肝炎和肝硬化同样有效。氨基比林呼气试验和单乙基甘氨酰二甲苯醚试验显示出良好的但不紧密的相关性。结论：这项研究表明，在肝硬化患者中，可以在前一天的3天后进行13C呼气试验。在慢性肝炎和肝硬化患者中，氨基比林呼气试验和单乙基甘氨糖苷试验评估的肝亚功能相似但不相同，这表明使用不同底物进行的多次13C呼气试验可以更好地探索肝脏功能。

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