In their seminal review in 2000, Hanahan and Weinberg described die hypodietical connection between apop-tosis and carcinogenesis. They stated that increased apoptosis should protect from malignant transformation rather than increase malignant transformation.5 The intracellular stresses that are induced by malignant transformation are highly apoptogenic (including lack of oxygen and nutrients, violation of cell cycle checkpoints, and others).
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