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Hepatitis C treatment in an urban population.

机译:城市人口中的丙型肝炎治疗。

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摘要

We read with interest the report by Feuerstadt et al. demonstrating the limited effectiveness of hepatitis C virus (HCV) therapy in an urban minority population. We evaluated 432 similar HCV-monoinfected patients and 392 human immunodeficiency virus (HIV)/HCV-coinfected patients and treated 45% and 21%, respectively. The baseline characteristics of our patients and theirs were similar, although more coinfected patients had advanced fibrosis (Table 1). Sustained virological response (SVR) was achieved in 21% of their subjects, 35% of our monoinfected patients, and 22% of our coinfected patients. In addition to the reported negative predictors of SVR, our coinfected patients had high mean HCV viral loads and a 14% prevalence of diabetes. A previous study of coinfection from our institution found a 76% prevalence of a homeostasis model assessment of insulin resistance score >3. Nasta et al. reported an 8% rapid virological response rate in coinfected patients with a high viral load and a homeostasis model assessment score >3.
机译:我们感兴趣地阅读了Feuerstadt等人的报告。证明丙型肝炎病毒(HCV)治疗在城市少数民族中的作用有限。我们评估了432例类似的HCV单一感染患者和392例人类免疫缺陷病毒(HIV)/ HCV合并感染患者,分别治疗了45%和21%。尽管更多合并感染的患者患有晚期纤维化,但我们患者的基线特征与他们的基线特征相似(表1)。持续的病毒学应答(SVR)在21%的受试者,35%的单感染患者和22%的合并感染患者中实现。除了已报道的SVR阴性预测指标外,我们的并发感染患者还具有较高的平均HCV病毒载量和14%的糖尿病患病率。我们机构先前对合并感染的研究发现,胰岛素抵抗评分> 3的稳态模型评估患病率为76%。 Nasta等。报道在病毒载量高且稳态模型评估得分> 3的合并感染患者中,病毒学快速反应率为8%。

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