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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study.
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Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study.

机译：脂肪肝与血脂异常和血糖异常无关，与内脏脂肪无关：Framingham心脏研究。

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摘要

Obesity is not uniformly associated with the development of metabolic sequelae. Specific patterns of body fat distribution, in particular fatty liver, may preferentially predispose at-risk individuals to disease. In this study, we characterize the metabolic correlates of fat in the liver in a large community-based sample with and without respect to visceral fat. Fatty liver was measured by way of multidetector computed tomography of the abdomen in 2,589 individuals from the community-based Framingham Heart Study. Logistic and linear regression were used to determine the associations of fatty liver with cardio-metabolic risk factors adjusted for covariates with and without adjustment for other fat depots (body mass index, waist circumference, and visceral adipose tissue). The prevalence of fatty liver was 17%. Compared with participants without fatty liver, individuals with fatty liver had a higher adjusted odds ratio (OR) of diabetes (OR 2.98, 95% confidence interval [CI] 2.12-4.21), metabolic syndrome (OR 5.22, 95% CI 4.15-6.57), hypertension (OR 2.73, 95% CI 2.16-3.44), impaired fasting glucose (OR 2.95, 95% CI 2.32-3.75), insulin resistance (OR 6.16, 95% CI 4.90-7.76); higher triglycerides, systolic blood pressure (SBP), and diastolic blood pressure (DBP); and lower high-density lipoprotein (HDL) and adiponectin levels (P < 0.001 for all). After adjustment for other fat depots, fatty liver remained associated with diabetes, hypertension, impaired fasting glucose, metabolic syndrome, HDL, triglycerides, and adiponectin levels (all P < 0.001), whereas associations with SBP and DBP were attenuated (P > 0.05). CONCLUSION: Fatty liver is a prevalent condition and is characterized by dysglycemia and dyslipidemia independent of visceral adipose tissue and other obesity measures. This work begins to dissect the specific links between fat depots and metabolic disease.
机译：肥胖与代谢后遗症的发展并非统一相关。身体脂肪分布的特定模式，特别是脂肪肝，可能会优先使处于危险中的人患上疾病。在这项研究中，我们表征了一个大的基于社区的样本中肝脏脂肪的代谢相关性，无论是否考虑内脏脂肪。通过基于社区的Framingham心脏研究的2589位患者的腹部多排计算机断层摄影术测量了脂肪肝。使用逻辑回归和线性回归确定脂肪肝与心脏代谢危险因素的关联，该危险因素针对协变量进行了调整，而对于其他脂肪库（体重指数，腰围和内脏脂肪组织）也进行了调整，而没有进行调整。脂肪肝的患病率为17％。与没有脂肪肝的参与者相比，患有脂肪肝的个体具有更高的糖尿病调整OR（OR）（OR 2.98，95％置信区间[CI] 2.12-4.21），代谢综合征（OR 5.22、95％CI 4.15-6.57） ），高血压（OR 2.73，95％CI 2.16-3.44），空腹血糖受损（OR 2.95，95％CI 2.32-3.75），胰岛素抵抗（OR 6.16，95％CI 4.90-7.76）;甘油三酸酯，收缩压（SBP）和舒张压（DBP）较高;以及较低的高密度脂蛋白（HDL）和脂联素水平（所有P均<0.001）。调整其他脂肪库后，脂肪肝仍与糖尿病，高血压，空腹血糖受损，代谢综合征，HDL，甘油三酸酯和脂联素水平相关（所有P <0.001），而与SBP和DBP的相关性减弱（P> 0.05） 。结论：脂肪肝是一种普遍的疾病，其特征在于血糖异常和血脂异常，独立于内脏脂肪组织和其他肥胖措施。这项工作开始剖析脂肪库与代谢疾病之间的具体联系。

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