Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease.

Browning JD; Cohen JC; Hobbs HH

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Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease.

机译：含Patatin样磷脂酶结构域3与小儿非酒精性脂肪性肝病的发病机制和进展。

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Nonalcoholic fatty liver disease (NAFLD), first recognized 30 years ago as a significant cause of liver-related morbidity and mortality, is now the most common cause of liver disease. The prevalence of hepatic steatosis in the pedi-atric population is estimated to be 10% and may be as high as 38% among obese children. Two-thirds of children with NAFLD and elevated aminotransferase levels have evidence of nonalcoholic steatohepatitis (NASH) on liver biopsy and are at risk for progressive liver disease and cirrhosis. Longitudinal studies of NAFLD suggest that the disease may progress more rapidly in children than in adults.

机译：非酒精性脂肪肝疾病（NAFLD）于30年前首次被认为是与肝脏相关的发病率和死亡率的重要原因，现在已成为最常见的肝病原因。小儿人群中肝脂肪变性的患病率估计为10％，在肥胖儿童中可能高达38％。三分之二患有NAFLD和转氨酶水平升高的儿童在肝活检中有非酒精性脂肪性肝炎（NASH）的证据，并且有进行性肝病和肝硬化的风险。 NAFLD的纵向研究表明，与成人相比，儿童的疾病进展更快。

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《Hepatology: Official Journal of the American Association for the Study of Liver Diseases》 |2010年第4期|共4页
作者
Browning JD; Cohen JC; Hobbs HH;
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正文语种 eng
中图分类消化系及腹部疾病;
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1. Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease. [J] . Browning JD, Cohen JC, Hobbs HH Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2010,第4期

机译：含Patatin样磷脂酶结构域3与小儿非酒精性脂肪性肝病的发病机制和进展。
2. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease. [J] . Rotman Y, Koh C, Zmuda JM, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2010,第3期

机译：含patatin样磷脂酶结构域蛋白3（PNPLA3）的遗传变异性与非酒精性脂肪肝疾病的组织学严重性相关。
3. Single cell characterization of patatin-like phospholipase domain-containing protein 3 (PNPLA3) transcription pattern in human liver biopsies of nonalcoholic fatty liver disease [J] . Sandhu Bynvant, Csizmadia Eva, Lai Michelle, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2017,第Suppla1期

机译：非酒精性脂肪肝疾病人肝活组织检查中含小蛋白样磷脂脂酶结构域域的蛋白质3（PNPLA3）转录模式的单细胞特征
4. Using text mining to understand traditional Chinese medicine pathogenesis of nonalcoholic fatty liver disease [C] . Hui-qin Zhang, Jian Li, Guang Zheng, IEEE International Conference on Bioinformatics and Biomedicine . 2013

机译：利用文本挖掘来了解非酒精性脂肪肝的中医发病机制
5. Sources of fatty acids in hepatic and lipoprotein triacylglycerol: Studies in transgenic mice, and in humans with nonalcoholic fatty liver disease. [D] . Peterson, Kerry Donnelly. 2005

机译：肝和脂蛋白三酰甘油中的脂肪酸来源：转基因小鼠和非酒精性脂肪肝患者的研究。
6. Association of patatin-like phospholipase domain-containing protein 3 gene polymorphisms with susceptibility of nonalcoholic fatty liver disease in a Han Chinese population [O] . Guohe Song, Chao Xiao, Kai Wang, -1

机译：汉族人群中patatin样磷脂酶结构域蛋白3基因多态性与非酒精性脂肪肝易感性的关系
7. The association of genetic variability in patatin-like phospholipase domain-containing protein 3 (PNPLA3) with histological severity of nonalcoholic fatty liver disease [O] . Yaron Rotman, Christopher Koh, Joseph M. Zmuda, 2010

机译：具有非酒精性脂肪肝疾病的组织学严重性的含小蛋白状磷脂酶结构域域的蛋白质3（PNPLA3）的遗传变异性

Patatin-like phospholipase domain-containing 3 and the pathogenesis and progression of pediatric nonalcoholic fatty liver disease.

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