...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >From NAFLD to NASH to fibrosis to HCC: Role of dendritic cell populations in the liver
【24h】

From NAFLD to NASH to fibrosis to HCC: Role of dendritic cell populations in the liver

机译：从NAFLD到NASH到纤维化再到HCC：树突状细胞群在肝脏中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dendritic cells (DCs) are particular hematopoi-etic cells that link the innate and adaptive part of immune responses. DCs, regularly found in lymphoid and nonlymphoid tissues, are specialized cells for presenting antigens in conjunction with major histocompatibility complex (MHC) class II molecules to T cells for initiating antigen-specific immune responses. Although DCs share certain characteristics, such as intracellular processing of phagocy-tized peptides and proteins for antigen presentation, migratory properties (toward the draining lymph node), and cytokine production, several functionally distinct DC subsets have been unraveled in mice and humans. However, most of these DC functions have been uncovered in infectious or autoimmune disease models in typical lymphoid organs, such as spleen or lymph nodes, and relatively little is known at present on the possible roles of DC populations in the liver. Moreover, given that many conditions of liver inflammation, such as nonalcoholic steatohepatitis (NASH), are classically considered noninfectious inflammatory reactions and are certainly not directed against a single antigen, unlike immune responses against viral proteins in viral hepatitis, the relevance of DCs for regulating sterile liver inflammation and fibrosis is even less clear. Nevertheless, independent studies had reported on the accumulation of myeloid cells with DC characteristics in experimental models of toxic and cholestatic liver diseases. " In this issue of Hepatology, Henning et al. explored the potential role of DCs in regulating hepatic inflammation and fibrogenesis in NASH (Fig. 1).
机译：树突状细胞（DC）是特定的造血细胞，它们连接免疫反应的固有和适应性部分。通常在淋巴组织和非淋巴组织中发现的DC是专门的细胞，用于将抗原和主要的组织相容性复合体（MHC）II类分子一起呈递给T细胞，以启动抗原特异性免疫反应。尽管DC具有某些特征，例如吞噬作用的肽和蛋白质在细胞内加工以呈递抗原，迁移特性（朝着引流淋巴结的方向）和细胞因子的产生，但在小鼠和人类中尚未阐明几个功能上不同的DC亚群。然而，在典型的淋巴器官如脾脏或淋巴结的传染性或自身免疫性疾病模型中，大多数这些DC功能尚未被发现，并且目前关于DC人群在肝脏中可能发挥的作用知之甚少。此外，鉴于许多肝脏炎症状况（例如非酒精性脂肪性肝炎（NASH））通常被认为是非感染性炎症反应，并且肯定不针对单一抗原，这与针对病毒性肝炎中针对病毒蛋白的免疫反应不同，DC对调节的重要性无菌肝脏炎症和纤维化甚至还不清楚。尽管如此，独立的研究已经报道了在毒性和胆汁淤积性肝病实验模型中具有DC特性的髓样细胞的积累。在本期肝病学中，Henning等人探讨了DC在调节NASH中的肝炎症和纤维发生中的潜在作用（图1）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号