Motor-evoked potentials in awake rats are a valid method of assessing hepatic encephalopathy and of studying its pathogenesis.

Oria M; Chatauret N; Chavarria L; Romero Gimenez J; Palenzuela L; Pardo Yules B; Arranz JA; Bodega G; Raguer N; Cordoba J

首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Motor-evoked potentials in awake rats are a valid method of assessing hepatic encephalopathy and of studying its pathogenesis.

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Motor-evoked potentials in awake rats are a valid method of assessing hepatic encephalopathy and of studying its pathogenesis.

机译：清醒大鼠中的运动诱发电位是评估肝性脑病和研究其发病机制的有效方法。

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Experimental models of hepatic encephalopathy (HE) are limited by difficulties in objectively monitoring neuronal function. There are few models that examine a well-defined neuronal pathway and lack the confounding effects of anesthetics. Motor-evoked potentials (MEPs) assess the function of the motor tract, which has been shown to be impaired in patients with cirrhosis. MEPs were elicited by cranial stimulation (central) and compound motor action potential by sciatic nerve stimulation (peripheral) in several models of HE in the rat. The experiments were performed using subcutaneous electrodes without anesthetics. Brain water content was assessed by gravimetry, brain metabolites were measured by magnetic resonance spectroscopy, and amino acids in microdialysates from the frontal cortex were analyzed by high-performance liquid chromatography. Abnormalities of MEP were observed in acute liver failure (ALF) induced by hepatic devascularization in relation to the progression of neurological manifestations. Similar disturbances were seen in rats with portocaval anastomosis after the administration of blood or lipopolysaccharide, but were absent in rats with biliary duct ligation. Hypothermia (

机译：肝性脑病（HE）的实验模型受到客观监测神经元功能困难的限制。很少有模型检查明确定义的神经元途径，并且缺乏麻醉药的混杂作用。运动诱发电位（MEP）评估运动功能，肝硬化患者已证明该功能受损。在大鼠的几种HE模型中，通过颅骨刺激（中央）和坐骨神经刺激（周围）产生复合运动电位。使用没有麻醉剂的皮下电极进行实验。用重量分析法测定脑水含量，用磁共振波谱法测定脑代谢产物，并用高效液相色谱法分析额叶皮层微量透析液中的氨基酸。观察到由肝血管血运重建引起的急性肝衰竭（ALF）中MEP的异常与神经学表现的进展有关。给予血液或脂多糖后，在门静脉吻合大鼠中也观察到类似的障碍，但在胆管结扎大鼠中则没有。体温过低（

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《Hepatology: Official Journal of the American Association for the Study of Liver Diseases》 |2010年第6期|共9页
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Oria M; Chatauret N; Chavarria L; Romero Gimenez J; Palenzuela L; Pardo Yules B; Arranz JA; Bodega G; Raguer N; Cordoba J;
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中图分类消化系及腹部疾病;
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机译：清醒大鼠中的运动诱发电位是评估肝性脑病和研究其发病机制的有效方法。
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Motor-evoked potentials in awake rats are a valid method of assessing hepatic encephalopathy and of studying its pathogenesis.

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