The report by Gazit et al. in this issue of Hepatology offers new insights into mechanisms of liver regeneration focusing on the contribution of peripheral lipid stores and systemic lipolysis in the liver's ability to regenerate in response to 70% partial hepatectomy. The present study was prompted by previous observations that partial hepatectomy induces transient hypoglycemia followed by lipid accumulation within hepatocytes that precedes the time of peak hepatocyte proliferation in mice.
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