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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Racial disparity in liver disease: Biological, cultural, or socioeconomic factors
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Racial disparity in liver disease: Biological, cultural, or socioeconomic factors

机译：肝病的种族差异：生物，文化或社会经济因素

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Chronic liver diseases are a major public health issue in the United States, and there are substantial racial disparities in liver cirrhosis-related mortality. Hepatitis C virus (HCV) is the most significant contributing factor in the development of chronic liver disease, complications such as hepatocellular carcinoma, and the need for liver transplantation. In the United States, African Americans have twice the prevalence of HCV seropositivity and develop hepatocellular carcinoma at more than twice the rate as whites. African Americans are, however, less likely to respond to interferon therapy for HCV than are whites and have considerably lower likelihood of receiving liver transplantation, the only definitive therapy for end-stage liver disease. Even among those who undergo transplantation, African Americans have lower 2-year and 5-year graft and patient survival compared to whites. We will review these racial disparities in chronic liver diseases and discuss potential biological, socioeconomic, and cultural contributions. An understanding of their underlying mechanisms is an essential step in implementing measures to mollify racially based inequities in the burden and management of liver disease in an increasingly racially and ethnically diverse population.
机译：慢性肝病是美国的主要公共卫生问题，在肝硬化相关的死亡率中存在重大种族差异。丙型肝炎病毒（HCV）是慢性肝病，肝细胞癌等并发症和肝移植需求发展中最重要的因素。在美国，非裔美国人的HCV血清阳性率为2倍，而肝细胞癌的发病率则是白人的两倍。但是，非裔美国人对HCV的干扰素治疗反应较白人更不可能，并且接受肝移植的可能性要低得多，这是终末期肝病的唯一确定疗法。甚至在接受移植的人中，与白人相比，非洲裔美国人的2年和5年移植物和患者存活率较低。我们将回顾慢性肝病中的种族差异，并讨论潜在的生物学，社会经济和文化贡献。了解其基本机制是在采取措施缓解种族和族裔日益多样化的人群中肝脏疾病负担和管理中基于种族的不平等现象的重要步骤。

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