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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes.
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Monocyte chemoattractant protein-1 secreted by adipose tissue induces direct lipid accumulation in hepatocytes.

机译：脂肪组织分泌的单核细胞趋化蛋白-1诱导脂质直接在肝细胞中蓄积。

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For many years, adipose tissue has been mainly considered as an inert reservoir for storing triglycerides. Since the discovery that adipocytes may secrete a variety of bioactive molecules (hormones, chemokines, and cytokines), an endocrine and paracrine role for white adipose tissue (WAT) in the regulation of energy balance and other physiological processes has been established, particularly with regard to brain and muscle. In contrast, little is known about the interactions of WAT with liver. Hence, we examined the effect of the secretory products of WAT on hepatocytes. Conditioned medium of human WAT explants induced significant steatosis in hepatocyte cell lines. Factor(s) responsible for the conditioned medium-induced steatosis were screened by a battery of blocking antibodies against different cytokines/chemokines shown to be secreted by WAT. In contrast to interleukin-8 and interleukin-6, the monocyte chemoattractant protein-1 was capable of inducing steatosis in hepatocytes in a time-dependent manner at concentrations similar to those found in conditioned medium. Incubation of conditioned medium with antimonocyte chemoattractant protein-1 antibodies prevented triglyceride accumulation. Investigation of the mechanism leading to the triglyceride accumulation showed that both a diminution of apolipoprotein B secretion and an increase in phosphoenolpyruvate carboxykinase messenger RNA may be involved. CONCLUSION: The monocyte chemoattractant protein-1 secreted by adipose tissue may induce steatosis not only recruiting macrophages but also acting directly on hepatocytes.
机译：多年来，脂肪组织主要被认为是用于储存甘油三酸酯的惰性贮存器。自发现脂肪细胞可分泌多种生物活性分子（激素，趋化因子和细胞因子）以来，已确立了白色脂肪组织（WAT）在调节能量平衡和其他生理过程中的内分泌和旁分泌作用，尤其是在到大脑和肌肉。相反，关于WAT与肝脏的相互作用知之甚少。因此，我们检查了WAT分泌产物对肝细胞的影响。人类WAT外植体的条件培养基可诱导肝细胞系发生明显脂肪变性。通过一系列针对显示由WAT分泌的不同细胞因子/趋化因子的封闭抗体，筛选导致条件培养基诱导的脂肪变性的因子。与白细胞介素8和白细胞介素6相比，单核细胞趋化蛋白1能够以时间依赖性的方式诱导肝细胞脂肪变性，其浓度与条件培养基中的浓度相似。将条件培养基与抗单核细胞趋化蛋白1抗体一起孵育可防止甘油三酸酯积聚。对导致甘油三酸酯积累的机制的研究表明，载脂蛋白B分泌的减少和磷酸烯醇丙酮酸羧激酶信使RNA的增加均可能参与。结论：脂肪组织分泌的单核细胞趋化蛋白-1可能引起脂肪变性，不仅招募巨噬细胞，而且直​​接作用于肝细胞。

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