...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Diagnostic accuracy of 18F-methylcholine positron emission tomography/computed tomography for intra- and extrahepatic hepatocellular carcinoma
【24h】

Diagnostic accuracy of 18F-methylcholine positron emission tomography/computed tomography for intra- and extrahepatic hepatocellular carcinoma

机译：18F-甲基胆碱正电子发射断层扫描/计算机断层扫描对肝内和肝外肝癌的诊断准确性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Diagnosis of hepatocellular carcinoma (HCC) primarily involves imaging. The aim of this study was to assess the accuracy of 18F-fluorocholine (18F-FCH) positron emission tomography (PET) for detection of HCC and evaluation of extent of disease. Patients with HCC 1 cm were included between 2009 and July 2011, and follow-up closed in February 2013. Diagnosis was based on American Association for the Study of Liver Diseases criteria, and all patients underwent 18F-FCH PET/computed tomography (CT) at baseline before treatment, 6 underwent a second PET/CT posttreatment, and 1 a third during follow-up. Whole-body PET and low-dose CT imaging were performed 15 minutes after 18F-FCH injection. Evaluation of imaging was done with standardized uptake value (SUV) ratios: SUV maximum of the lesion divided by the SUV mean of surrounding tissue. Statistical analyses included descriptive analyses, receiver operating characteristic curve, McNemar's test, and Kaplan-Meier's test at 5% level of significance. Twenty-nine patients revealed 53 intrahepatic lesions. In 48 of 53 lesions, 18F-FCH PET was positive (SUVratio, 1.95±0.66; sensitivity, 88%; specificity, 100%). PET/CT showed uptake in 18 extrahepatic lesions and no uptake in 3 lesions affirmed non-HCC lesions; all lesions were confirmed with additional investigation (accuracy, 100%). In 17 of 29 patients, additional lesions were found on PET/CT imaging, with implications for treatment in 15 patients. Posttreatment PET/CT showed identical results, compared with standard treatment evaluation. Conclusion: This study shows additional value of 18F-FCH PET/CT for patients with HCC. 18F-FCH PET/CT has implications for staging, management, and treatment evaluation because of accurate assessment of extrahepatic disease.
机译：肝细胞癌（HCC）的诊断主要涉及影像学。这项研究的目的是评估18 F-氟胆碱（18F-FCH）正电子发射断层扫描（PET）用于检测HCC和评估疾病程度的准确性。 HCC> 1 cm的患者在2009年至2011年7月之间被纳入研究，并于2013年2月结束随访。诊断基于美国肝病研究协会的标准，所有患者均接受了18F-FCH PET /计算机断层扫描（CT） ）在治疗前的基线水平，其中6例接受了第二次PET / CT后处理，而1例在随访中接受了三分之一。 18F-FCH注射后15分钟进行全身PET和低剂量CT成像。用标准摄取值（SUV）比率进行成像评估：病变的SUV最大值除以周围组织的SUV平均值。统计分析包括描述性分析，接收器工作特性曲线，McNemar检验和Kaplan-Meier检验（显着性水平为5％）。 29例患者显示53个肝内病变。在53个病变中的48个中，18F-FCH PET阳性（SUVratio，1.95±0.66;敏感性，88％;特异性，100％）。 PET / CT显示有18个肝外病灶被摄取，而3个病灶中的非摄取证实为非HCC病灶。所有病变均需进一步检查（准确性，100％）。在29例患者中的17例中，通过PET / CT成像发现了其他病变，对15例患者的治疗意义重大。与标准治疗评估相比，后处理PET / CT显示相同的结果。结论：这项研究显示了18F-FCH PET / CT对肝癌患者的附加价值。由于对肝外疾病的准确评估，18F-FCH PET / CT对分期，管理和治疗评估具有影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号