Hepatic lipid droplet biology: Getting to the root of fatty liver

Mashek Douglas G.; Khan Salmaan A.; Sathyanarayan Aishwarya; Ploeger Jonathan M.; Franklin Mallory P.

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Hepatic lipid droplet biology: Getting to the root of fatty liver

机译：肝脂质小滴生物学：深入脂肪肝

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Hepatic steatosis is defined by the accumulation of lipid droplets (LDs). Once thought to be only inert energy storage depots, LDs are increasingly recognized as organelles that have important functions in hepatocytes beyond lipid storage. The lipid and protein composition of LDs is highly dynamic and influences their intrinsic metabolism and signaling properties, which ultimately links them to the changes in hepatic function. This concise review highlights recent discoveries in LD biology and unique aspects of hepatic LDs and their role in liver disease. (Hepatology 2015;62:964-967)

机译：肝脂肪变性是由脂质滴（LDs）的积累定义的。 LDs曾经被认为只是惰性的能量存储库，因此越来越多地被认为是细胞器，除了脂质存储外，它们在肝细胞中还具有重要的功能。 LD的脂质和蛋白质组成是高度动态的，并影响其固有的代谢和信号传导特性，最终将它们与肝功能的变化联系起来。这篇简明的综述着重介绍了LD生物学的最新发现以及肝LD的独特方面及其在肝病中的作用。（肝病2015; 62：964-967）

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《Hepatology: Official Journal of the American Association for the Study of Liver Diseases》 |2015年第3期|共4页
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Mashek Douglas G.; Khan Salmaan A.; Sathyanarayan Aishwarya; Ploeger Jonathan M.; Franklin Mallory P.;
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正文语种 eng
中图分类消化系及腹部疾病;
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1. Hepatic lipid droplet biology: Getting to the root of fatty liver [J] . Mashek Douglas G., Khan Salmaan A., Sathyanarayan Aishwarya, Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2015,第3期

机译：肝脂质小滴生物学：深入脂肪肝
2. Isolation of Micro- and Macro-Droplet Fractions from Needle Biopsy Specimens of Human Liver and Determination of the Subcellular Distribution of the Accumulating Liver Lipids in Alcoholic Fatty Liver [J] . S. R. Cairns, T. J. Peters Clinical Science . 1984,第3期

机译：从人肝穿刺活检标本中分离出微小和宏观液滴部分，并测定酒精性脂肪肝中积累的肝脂质的亚细胞分布
3. A New Targeted Lipidomics Approach Reveals Lipid Droplets in Liver, Muscle and Heart as a Repository for Diacylglycerol and Ceramide Species in Non-Alcoholic Fatty Liver [J] . Christina Preuss, Tomas Jelenik, Kálmán Bódis, Cells . 2019,第3期

机译：一种新的靶向脂质组学方法揭示了肝脏，肌肉和心脏中的脂质小滴，作为非酒精性脂肪肝中二酰基甘油和神经酰胺物质的储存库
4. DEVELOPING PRACTICAL APPROACHES TO MODIFY HEPATIC FATTY ACID PROCESSING AND LIPID MEDIATOR BIOSYNTHESIS IN DAIRY CATTLE: THE EMERGING ROLE OF LIPIDOMICS [C] . Cornell Nutrition Conference for Feed Manufacturers . 2017

机译：制定切换肝脏脂肪酸加工和脂质介质生物合成的实用方法：脂类物学的新兴作用
5. The role of adipose triglyceride lipase in hepatic lipid metabolism, non-alcoholic fatty liver disease and insulin resistance. [D] . Ong, Kuok Teong. 2013

机译：脂肪甘油三酸酯脂肪酶在肝脂质代谢，非酒精性脂肪肝疾病和胰岛素抵抗中的作用。
6. Hepatic lipid droplet biology: getting to the root of fatty liver [O] . Douglas G. Mashek, Salmaan A. Khan, Aishwarya Sathyanarayan, -1

机译：肝脂质微滴生物学：深入脂肪肝
7. A New Targeted Lipidomics Approach Reveals Lipid Droplets in Liver, Muscle and Heart as a Repository for Diacylglycerol and Ceramide Species in Non-Alcoholic Fatty Liver [O] . Christina Preuss, Tomas Jelenik, Kálmán Bódis, 2019

机译：一种新的靶向脂质化学方法揭示了肝脏，肌肉和心脏的脂质液滴作为非酒精脂肪肝中的二酰基甘油和神经酰胺种类的储存库

Hepatic lipid droplet biology: Getting to the root of fatty liver

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