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首页> 外文期刊>Hepatology: Official Journal of the American Association for the Study of Liver Diseases >Combination of splanchnic vasoconstrictors and endoscopic band ligation is an effective treatment strategy for acute variceal hemorrhage; But how do we get those drugs approved by the FDA?
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Combination of splanchnic vasoconstrictors and endoscopic band ligation is an effective treatment strategy for acute variceal hemorrhage; But how do we get those drugs approved by the FDA?

机译：内脏血管收缩剂和内镜带结扎术相结合是急性静脉曲张破裂出血的有效治疗策略。但是我们如何获得FDA批准的那些药物呢？

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摘要

Acute gastroesophageal variceal hemorrhage is one of the defining clinical complications of decompensated cirrhosis and carries high morbidity and mortality. There have been significant advances in the medical management over the last 20 years for variceal hemorrhage, including the integration of endoscopic band ligation, vasoactive drugs, and antibiotic prophylaxis as standard of care. However, acute gastroesophageal variceal hemorrhage still carries a 6-week mortality rate of 15-20%.
机译：急性胃食管静脉曲张破裂出血是失代偿性肝硬化的定义性临床并发症之一，并具有较高的发病率和死亡率。在过去的20年中，静脉曲张破裂出血的医疗管理取得了重大进展，其中包括将内窥镜结扎术，血管活性药物和抗生素预防作为治疗标准。但是，急性胃食管静脉曲张破裂出血的6周死亡率仍为15-20％。

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