Cyclic guanosine monophosphate/adenosine monophosphate synthase (cGAS), innate immune responses, and viral hepatitis

VerrierE.R.; GackM.U.; BaumertT.F.

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Cyclic guanosine monophosphate/adenosine monophosphate synthase (cGAS), innate immune responses, and viral hepatitis

机译：环状鸟苷一磷酸/腺苷一磷酸合酶（cGAS），先天免疫应答和病毒性肝炎

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The type I interferon (IFN) response protects cells from viral infection by inducing hundreds of interferon-stimulated genes (ISGs), some of which encode direct antiviral effectors. Recent screening studies have begun to catalogue ISGs with antiviral activity against several RNA and DNA viruses. However, antiviral ISG specificity across multiple distinct classes of viruses remains largely unexplored. Here we used an ectopic expression assay to screen a library of more than 350 human ISGs for effects on 14 viruses representing 7 families and 11 genera. We show that 47 genes inhibit one or more viruses, and 25 genes enhance virus infectivity. Comparative analysis reveals that the screened ISGs target positive-sense single stranded RNA viruses more effectively than negative-sense single stranded RNA viruses.

机译：I型干扰素（IFN）响应通过诱导数百种干扰素刺激基因（ISG）来保护细胞免受病毒感染，其中某些基因编码直接的抗病毒效应子。最近的筛选研究已开始对具有针对几种RNA和DNA病毒的抗病毒活性的ISG进行分类。但是，在多种不同类别的病毒中，抗病毒ISG的特异性仍未开发。在这里，我们使用异位表达试验筛选了350多个人ISG的文库，以研究代表7个科和11个属的14种病毒的影响。我们显示47基因抑制一种或多种病毒，而25基因增强病毒的感染性。对比分析显示，筛选出的ISG比负链单链RNA病毒更有效地靶向正链单链RNA病毒。

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《Hepatology: Official Journal of the American Association for the Study of Liver Diseases》 |2014年第3期|共3页
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VerrierE.R.; GackM.U.; BaumertT.F.;
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中图分类消化系及腹部疾病;
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1. Cyclic guanosine monophosphate/adenosine monophosphate synthase (cGAS), innate immune responses, and viral hepatitis [J] . VerrierE.R., GackM.U., BaumertT.F. Hepatology: Official Journal of the American Association for the Study of Liver Diseases . 2014,第3期

机译：环状鸟苷一磷酸/腺苷一磷酸合酶（cGAS），先天免疫应答和病毒性肝炎
2. Cyclic adenosine monophosphate and cyclic guanosine monophosphate-phosphodiesterase isoenzymes in human vagina: relation to nitric oxide synthase isoforms and vasoactive intestinal polypeptide-containing nerves. [J] . Uckert S, Oelke M, Waldkirch E, Urology . 2005,第3期

机译：人阴道中的环腺苷单磷酸和环鸟苷单磷酸-磷酸二酯酶同工酶：与一氧化氮合酶同工型和含血管活性肠多肽的神经有关。
3. Cyclic Dimeric Guanosine Monophosphate: Activation and Inhibition of Innate Immune Response [J] . Cui T., Cang H., Yang B., Journal of innate immunity . 2019,第3期

机译：环二聚鸟苷单磷酸：激活和抑制先天免疫反应。
4. Fast Cleavage of 3'5'-Cyclic Adenosine Monophosphate and 3'5'-Cyclic Guanosine Monophosphate by Lanthanides [C] . Li Xin-Min, Zhu Bing, Wu Yi-Jie, International conferenc on rare earth development and applications . 1995

机译：镧系元素快速切割3'5'-环腺苷单磷酸和3'5'-环鸟苷单磷酸
5. Role for cyclic adenosine monophosphate(cAMP) response element binding proteins in B lymphocyte development and functional maturation. [D] . Chen, Hui-Chen. 2003

机译：环状单磷酸腺苷（cAMP）反应元件结合蛋白在B淋巴细胞发育和功能成熟中的作用。
6. Parenteral immunization with a cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) adjuvanted [O] . Jing Chen, Youxiu Zhong, Yu Liu, 2020

机译：用环磷酸单磷酸腺苷 - 腺苷二磷酸胺（CGAMP）佐剂肠外免疫
7. Cyclic guanosine monophosphate/adenosine monophosphate synthase (cGAS), innate immune responses, and viral hepatitis [O] . Eloi R. Verrier, Michaela U. Gack, Thomas F. Baumert 2014

机译：循环鸟苷一体单磷酸/腺苷一磷酸合酶（CGA），先天免疫应答和病毒性肝炎
8. Morphine Reduces Cerebellar Guanosine-3',5'-Cyclic Monophosphate Content and Elevates Cerebrospinal Fluid Guanosine-3',5'-Cyclic Monophosphate Content in Rhesus Monkey. [R] . Katz, J. B., Catravas, G. N., Valases, C., 1977

机译：吗啡减少小脑鸟嘌呤-3'，5'-环单磷酸含量并提高恒河猴脑脊液中鸟苷-3'，5'-环磷酸单酯含量。

Cyclic guanosine monophosphate/adenosine monophosphate synthase (cGAS), innate immune responses, and viral hepatitis

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