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首页> 外文期刊>Hematology/Oncology Clinics of North America >Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer
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Therapeutic Opportunities in the Intrinsic Subtypes of Muscle-Invasive Bladder Cancer

机译：肌浸润性膀胱癌的固有亚型的治疗机会

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摘要

Recent studies revealed that muscle-invasive bladder cancers segregate into intrinsic basal and luminal subtypes that are similar to those described for breast cancer. Each subtype is enriched with potentially clinically actionable genomic alterations and epigenetic signatures; there are associations between tumor subtype and sensitivity to conventional cisplatin-based chemotherapy. The authors review biological and clinical characteristics of the intrinsic subtypes and describe their implications for the development of conventional and targeted agents. The role that tumor plasticity seems to play in basal and luminal bladder cancer biology and its potential effects on the development of therapeutic resistance is also discussed.
机译：最近的研究表明，肌肉浸润性膀胱癌可分为固有的基础和管腔亚型，与乳腺癌中描述的相似。每个亚型都富含潜在的可在临床上应用的基因组改变和表观遗传学特征。肿瘤亚型与常规顺铂化疗敏感性之间存在关联。作者回顾了固有亚型的生物学和临床特征，并描述了它们对常规药物和靶向药物发展的影响。还讨论了肿瘤可塑性似乎在基底和管腔膀胱癌生物学中的作用及其对治疗耐药性发展的潜在影响。

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