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首页> 外文期刊>Hematology/Oncology Clinics of North America >Molecular Biology of Bladder Cancer
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Molecular Biology of Bladder Cancer

机译:膀胱癌的分子生物学

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摘要

Classic as well as more recent large-scale genomic analyses have uncovered multiple genes and pathways important for bladder cancer development. Genes involved in cell-cycle control, chromatin regulation, and receptor tyrosine and PI3 kinase-mammalian target of rapamycin signaling pathways are commonly mutated in muscle-invasive bladder cancer. Expression-based analyses have identified distinct types of bladder cancer that are similar to subsets of breast cancer, and have prognostic and therapeutic significance. These observations are leading to novel therapeutic approaches in bladder cancer, providing optimism for therapeutic progress.
机译:经典以及最近进行的大规模基因组分析都发现了对膀胱癌发展至关重要的多种基因和途径。雷帕霉素信号传导途径中涉及细胞周期控制,染色质调节,受体酪氨酸和PI3激酶-哺乳动物靶标的基因通常在肌肉浸润性膀胱癌中发生突变。基于表达的分析已鉴定出与乳腺癌子集相似的不同类型的膀胱癌,并具有预后和治疗意义。这些发现导致了膀胱癌的新颖治疗方法,为治疗进展提供了乐观。

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