Significant frequency of MSH2/MSH6 abnormality in ovarian endometrioid carcinoma supports histotype-specific Lynch syndrome screening in ovarian carcinomas

Rambau Peter F.; Duggan Maire A.; Ghatage Prafull; Warfa Khadija; Steed Helen; Perrier Renee; Kelemen Linda E.; Kobel Martin

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Significant frequency of MSH2/MSH6 abnormality in ovarian endometrioid carcinoma supports histotype-specific Lynch syndrome screening in ovarian carcinomas

机译：卵巢子宫内膜样癌中MSH2 / MSH6异常的显着频率支持卵巢癌中组织型特异性Lynch综合征的筛查

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AimsLynch syndrome screening in ovarian carcinoma is controversial. The aim of this study was to assess the frequency of deficient mismatch repair (dMMR) protein in a retrospective cohort enriched for non-high-grade serous carcinomas and its association with outcome within histological types.

机译：卵巢癌的AimsLynch综合征筛查是有争议的。这项研究的目的是评估回顾性队列中缺乏高级别浆液性癌的缺陷错配修复（dMMR）蛋白的频率及其与组织学类型结局的关系。

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《Histopathology: Official Journal of the British Division of the International Academy of Pathology》 |2016年第2期|共10页
作者
Rambau Peter F.; Duggan Maire A.; Ghatage Prafull; Warfa Khadija; Steed Helen; Perrier Renee; Kelemen Linda E.; Kobel Martin;
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正文语种 eng
中图分类病理学;
关键词
histotype-specific; immunohistochemistry; mismatch repair proteins; ovarian carcinoma;

机译：组织特异性;免疫组化;错配修复蛋白;卵巢癌;

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1. Significant frequency of MSH2/MSH6 abnormality in ovarian endometrioid carcinoma supports histotype-specific Lynch syndrome screening in ovarian carcinomas [J] . Rambau Peter F., Duggan Maire A., Ghatage Prafull, Histopathology: Official Journal of the British Division of the International Academy of Pathology . 2016,第2期

机译：卵巢子宫内膜样癌中MSH2 / MSH6异常的显着频率支持卵巢癌中组织型特异性Lynch综合征的筛查
2. The histomorphology of lynch syndrome-associated ovarian carcinomas: Toward a subtype-specific screening strategy [J] . ChuiM.H., RyanP., RadiganJ., American Journal of Surgical Pathology . 2014,第9期

机译：淋巴综合征相关的卵巢癌的组织形态学：寻求亚型特异性筛选策略
3. Immunohistochemical comparison of ovarian and uterine endometrioid carcinoma, endometrioid carcinoma with clear cell change, and clear cell carcinoma [J] . Lim, D., Ip, American Journal of Surgical Pathology . 2015,第8期

机译：卵巢和子宫子宫内甲状腺癌，子宫内膜改变的免疫组织化学比较，细胞癌细胞癌和透明细胞癌
4. Identification of Marker Genes Discriminating the Pathological Stages in Ovarian Carcinoma by Using Support Vector Machine and Systems Biology [C] . Meng-Hsiun Tsai, Jun-Dong Chang, Sheng-Hsiung Chiu, Australian Conference on Progress in Artificial Life(ACAL 2007); 20071204-06; Gold Coast(AU) . 2007

机译：利用支持向量机和系统生物学技术鉴定可区分卵巢癌病理分期的标记基因
5. Functional Characterization and Modeling of Factors Involved in High Grade Serous Ovarian Carcinoma Initiation [D] . Yamulla, Robert Joseph. 2020

机译：高级浆液癌癌癌中涉及的功能表征及造型
6. Metastatic colorectal carcinoma mimicking primary ovarian carcinoma presenting as ‘giant’ ovarian tumors in an individual with probable Lynch syndrome: a case report [O] . Peter A Ongom, Michael Odida, Robert L Lukande, 2013

机译：转移性大肠癌模仿原发性卵巢癌在可能的林奇综合征患者中表现为巨大卵巢肿瘤：一例病例报告
7. Metastatic colorectal carcinoma mimicking primary ovarian carcinoma presenting as ‘giant’ ovarian tumors in an individual with probable Lynch syndrome: a case report [O] . Peter A Ongom, Michael Odida, Robert L Lukande, 2013

机译：转移性大肠癌模仿原发性卵巢癌，在可能的林奇综合征患者中表现为“巨大”卵巢肿瘤：一例病例报告

Significant frequency of MSH2/MSH6 abnormality in ovarian endometrioid carcinoma supports histotype-specific Lynch syndrome screening in ovarian carcinomas

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