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首页> 外文期刊>Histochemistry and cell biology >Interrelations between monoaminergic afferents and corticotropin-releasing factor-immunoreactive neurons in the rat central amygdaloid nucleus: ultrastructural evidence for dopaminergic control of amygdaloid stress systems
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Interrelations between monoaminergic afferents and corticotropin-releasing factor-immunoreactive neurons in the rat central amygdaloid nucleus: ultrastructural evidence for dopaminergic control of amygdaloid stress systems

机译：大鼠杏仁核中央核中单胺能传入分子与促肾上腺皮质激素释放因子免疫反应性神经元之间的相互关系：多巴胺能控制杏仁体应激系统的超微结构证据

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Ample evidence implicates corticotropin-releasing factor (CRF)-producing neurons of the central amygdaloid nucleus (CeA) in vegetative, endocrine, and behavioral responses to stress and anxiety in laboratory rats. Monoaminergic systems are involved in modulating these responses. In the present paper, interrelations between CRF-immunoreactive (ir) neurons, and noradrenergic, serotonergic, and dopaminergic afferents were studied using single and double immunolabeling for light and electron microscopy in the rat CeA. Dopaminergic axons formed dense plexus in the CeA overlapping with the localization of CRF-ir neurons, and their terminals formed frequent associations with CRF-ir somata. Contacts of serotonergic axons on CRF-ir neurons were few, and contacts of noradrenergic axons were the exception. Ultrastructurally, symmetric synapses of dopaminergic terminals on CRF-ir somata and dendrites were found. More than 83% of CRF-ir somata were contacted in single ultrathin sections. About half of these possessed two or more contacts. of non-ir somata, 37% were contacted by dopaminergic terminals, and only 13% of these had two or more contacts. Correlative in situ hybridization indicated that CeA CRF-ir neurons may express receptor subtype dopamine receptor subtype 2. In conclusion, dopaminergic afferents appear to specifically target CeA CRF neurons. They are thus in a position to exert significant influence on the rat amygdaloid CRF stress system.
机译：充足的证据表明在实验室大鼠中，植物杏仁，杏仁核（CeA）的营养，内分泌以及行为对应激和焦虑的反应均会产生促肾上腺皮质激素释放因子（CRF）。单胺能系统参与调节这些反应。在本文中，使用单次和两次免疫标记法对大鼠CeA进行了CRF免疫反应性（ir）神经元与去甲肾上腺素能，血清素能和多巴胺能传入性之间的相互关系。多巴胺能轴突在CeA中形成密集的神经丛，与CRF-ir神经元的定位重叠，并且它们的末端与CRF-ir躯体形成频繁的关联。血清素能神经轴突在CRF-ir神经元上的接触很少，而去甲肾上腺素能轴突的接触除外。在超微结构上，发现了CRF-ir躯体和树突上多巴胺能末端的对称突触。在单个超薄切片中接触了超过83％的CRF-ir躯体。其中约有一半拥有两个或多个联系。在非ir躯体中，有37％通过多巴胺能终端接触，只有13％有两次或多次接触。相关的原位杂交表明，CeA CRF-ir神经元可能表达受体亚型多巴胺受体亚型2。总而言之，多巴胺能传入似乎针对了CeA CRF神经元。因此，它们可以对大鼠杏仁核CRF应激系统产生重要影响。

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