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首页> 外文期刊>Helvetica chimica acta >Application of a potentiometric system with data-analysis computer programs to the quantification of metal-chelating activity of two natural antioxidants: Caffeic acid and ferulic acid
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Application of a potentiometric system with data-analysis computer programs to the quantification of metal-chelating activity of two natural antioxidants: Caffeic acid and ferulic acid

机译：带有数据分析计算机程序的电位系统在定量两种天然抗氧化剂（咖啡酸和阿魏酸）的金属螯合活性中的应用

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The quantification of metal-chelating activity of caffeic and ferulic acids (1 and 2. resp.) was successfully performed by using a potentiometric system with data-analysis computer programs. The method was applied to two phenolic models, which have been systematically reported as antioxidants. Although a chain-breaking mechanism was proposed, several studies pointed out the possibility of complexation of transition metals that can participate in single-electron reactions and mediate the formation of oxygen-derived free radicals. In this work, the complexation properties towards Cu-11 were investigated by potentiometry with a glass electrode. Acidity constants of the ligands (phenolic acids) and the formation constants of the ligand-metal complexes were evaluated by potentiometry. The modeling of the titration curves and the data treatment were performed with the computer programs Superquad and Best. A detailed quantitative examination of the complexation species formed in the Cu-11/caffeic acid (1) and Cu-11/ferulic acid (2) systems is presented together with the formation constants (log P). Results have shown that the complexation properties of the two phenolic acids towards the transition metal are quite different: the activity of caffeic acid (1) was found higher than that of ferulic acid (2). ne data are important to get insight into the mechanism of action of antioxidants. and. in this case, could partially explain the efficacy of caffeic acid in the protection of LDL oxidative damage. In addition. the analytical method developed could be applied to quantify the chelating activity of important biological compounds, such as allopurinol, uric acid, cinnamic acids, flavonoids, and anthocianins, and, in that way, could be a valuable tool to understand the mechanisms underlying their protective effects. [References: 26]
机译：通过使用带有数据分析计算机程序的电位计系统，可以成功地定量分析咖啡酸和阿魏酸（分别为1和2）的金属螯合活性。该方法已应用于两种酚醛模型，已被系统报告为抗氧化剂。尽管提出了断链机理，但是一些研究指出了过渡金属络合的可能性，该过渡金属可以参与单电子反应并介导氧衍生自由基的形成。在这项工作中，通过使用玻璃电极的电位法研究了对Cu-11的络合性能。配位体（酚酸）的酸度常数和配位体-金属络合物的形成常数通过电位计评估。滴定曲线的建模和数据处理使用计算机程序Superquad和Best进行。给出了对在Cu-11 /咖啡酸（1）和Cu-11 /阿魏酸（2）系统中形成的络合物种的详细定量检查以及形成常数（log P）。结果表明，两种酚酸对过渡金属的络合性质非常不同：发现咖啡酸（1）的活性高于阿魏酸（2）的活性。新数据对于深入了解抗氧化剂的作用机理很重要。和。在这种情况下，可以部分解释咖啡酸在保护LDL氧化损伤中的功效。此外。开发的分析方法可用于量化重要生物化合物的螯合活性，例如别嘌醇，尿酸，肉桂酸，类黄酮和花青素，因此，它可能是了解保护其潜在机制的有价值的工具效果。 [参考：26]

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